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D4641

n-Dodecyl β-D-maltoside

≥98% (GC)

Synonym(s):

DDM, Lauryl-β-D-maltoside

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500 MG

$179.00

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$258.00

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$869.00

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$3,240.00

$179.00


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About This Item

Empirical Formula (Hill Notation):
C24H46O11
CAS Number:
Molecular Weight:
510.62
NACRES:
NA.25
PubChem Substance ID:
eCl@ss:
32190102
UNSPSC Code:
12161900
MDL number:
Beilstein/REAXYS Number:
55318

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InChI

1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20-,21-,22-,23-,24-/m1/s1

SMILES string

CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O

InChI key

NLEBIOOXCVAHBD-QKMCSOCLSA-N

biological source

corn

description

non-ionic

assay

≥98% (GC)

form

powder

mol wt

micellar avg mol wt 50,000

aggregation number

98

technique(s)

protein quantification: suitable

impurities

<1.5% water (Karl Fischer)

CMC

0.15 mM (20-25°C)

mp

224-226 °C (lit.)

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

storage temp.

−20°C

Quality Level

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1 of 4

This Item
D5172324355D7658
technique(s)

protein quantification: suitable

technique(s)

protein purification: suitable, protein quantification: suitable

technique(s)

-

technique(s)

-

form

powder

form

powder

form

solid

form

powder

assay

≥98% (GC)

assay

≥98% (GC)

assay

≥98% (HPLC)

assay

≥98% (GC)

aggregation number

98

aggregation number

98

aggregation number

98

aggregation number

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

impurities

<1.5% water (Karl Fischer)

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

impurities

≤1% dodecanol 1H NMR

impurities

-

General description

N-dodecyl-β-D-maltoside, also known as Lauryl Maltoside, stands as a non-ionic surfactant and derivative of pyrene (Py). Functioning as an alkyl maltopyranoside detergent, it excels particularly in the solubilization and crystallization of membrane proteins, making it a crucial tool in cell biology and biochemical research. Its unique capability arises from its adeptness at forming micelles that mimic the membrane environment, thereby preserving the α-helical structures and native conformations of membrane-associated proteins.

In addition to its primary function, N-dodecyl-β-D-maltoside has diverse applications, including the purification and stabilization of RNA polymerase, the detection of protein-lipid interactions, and serving as a substrate for glucosyl and xylosyl transfer by glycogenin. Its mild and non-denaturing properties have further led to its utilization in protein-anesthetic studies. Overall, N-dodecyl-β-D-maltoside emerges as a versatile detergent with a broad range of applications in membrane protein research and beyond. Its pivotal role in preserving protein structure and function establishes it as an indispensable tool for exploring the intricacies of membrane biology.

Application

Non-ionic detergent for the stabilization and activation of enzymes and for membrane research.
Non-ionic detergent used to extract and solubilize proteins.
n-Dodecyl β-D-maltoside has been used in a study to assess the mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques. [1]

Features and Benefits

  • Highly versatile surfactant for your cell biology and biochemical research
  • Suitable for protein quantification

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Kenneth P Watkins et al.
The Plant journal : for cell and molecular biology, 102(2), 369-382 (2019-12-04)
Synthesis of the D1 reaction center protein of Photosystem II is dynamically regulated in response to environmental and developmental cues. In chloroplasts, much of this regulation occurs at the post-transcriptional level, but the proteins responsible are largely unknown. To discover
Ka Young Chung et al.
The Journal of biological chemistry, 287(43), 36305-36311 (2012-08-16)
The G protein-coupled β(2)-adrenoreceptor (β(2)AR) signals through the heterotrimeric G proteins G(s) and G(i) and β-arrestin. As such, the energy landscape of β(2)AR-excited state conformers is expected to be complex. Upon tagging Cys-265 of β(2)AR with a trifluoromethyl probe, (19)F
Ryutaro Tokutsu et al.
The Journal of biological chemistry, 287(37), 31574-31581 (2012-07-18)
Photosystem II (PSII) is a multiprotein complex that splits water and initiates electron transfer in photosynthesis. The central part of PSII, the PSII core, is surrounded by light-harvesting complex II proteins (LHCIIs). In higher plants, two or three LHCII trimers
Antonello Calcutta et al.
Biochimica et biophysica acta, 1818(9), 2290-2301 (2012-04-25)
Membrane proteins are vital for biological function, and their action is governed by structural properties critically depending on their interactions with the membranes. This has motivated considerable interest in studies of membrane protein folding and unfolding. Here the structural changes
Signe Beck Petersen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 701-712 (2012-09-07)
Alkylmaltosides are a class of non-ionic surfactant currently in clinical trials to improve nasal permeation of peptide drugs, however few studies have detailed their potential effects on intestinal permeation enhancement. Tetradecyl maltoside (TDM, C(14)), was examined in Caco-2 monolayers and

Protocols

This page shows how to solubilize membrane proteins with products from Cytiva.

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Product Information Sheet

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. How stable is n-Dodecyl β-D-maltoside (D4641 or D5172) once it is dissolved?

    1 answer
    1. The product should not be stored for more than one day once it is dissolved.

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