D7802

Daidzein

≥98%, synthetic

• Synonym(s): 7-Hydroxy-3-(4-hydroxy­phenyl)­chromone, 7-Hydroxy-3-(4-hydroxy­phenyl)-4H-1-benzo­pyran-4-one, Isoaurostatin, 4′,7-Dihydroxy­iso­flavone
• Empirical Formula (Hill Notation): C₁₅H₁₀O₄
• CAS Number: 486-66-8
• Molecular Weight: 254.24
• Beilstein: 231523
• EC Number: 207-635-4
• MDL number: MFCD00016954
• PubChem Substance ID: 24278030
• NACRES: NA.77

Properties

• Quality Level: 200
• biological source: synthetic
• assay: ≥98%
• form: powder
• mp: >290 °C
• solubility: DMSO: 10 mg/mL
• storage temp.: −20°C
• SMILES string: Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O
• InChI: 1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
• InChI key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N
• Gene Information: human ... ESR1(2099) , ESR2(2100) , UGT1A4(54657) ; mouse ... Aldh1a2(19378) , Hexa(15211) , Maoa(17161) ; rat ... Aldh1a2(116676)

Description

General description

Daidzein is an isoflavone present in soy. It regulates oxidative stress, angiogenesis, cell growth and apoptosis. Daidzein has antioxidant, antiestrogenic and antiatherogenic properties. It provides protection against osteoporosis.

Application

Daidzein has been used:

• as a control to evaluate fertility in rats
• to study its effects on ovarian cancer
• to simulate in vitro antioxidant activity

Packaging

25 mg in poly bottle

100 mg in glass bottle

Packaged under Argon.

Biochem/physiol Actions

Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers. Arrests cell cycle at G₁ in Swiss 3T3 cells.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves