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E8909

Sigma-Aldrich

Phosphodiesterase 3B

recombinant, expressed in Sf9 cells

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Synonym(s):
3′,5′-cyclic-nucleotide phosphodiesterase, PDE 3B
Enzyme Commission number:
MDL number:
NACRES:
NA.54

recombinant

expressed in Sf9 cells

Quality Level

form

buffered aqueous solution

specific activity

≥1000 units/μg protein

shipped in

dry ice

storage temp.

−70°C

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This Item
E9034SAB4200693C9743
Sigma-Aldrich

E8909

Phosphodiesterase 3B

Sigma-Aldrich

E9034

Phosphodiesterase 5A1 human

form

buffered aqueous solution

form

solution

form

buffered aqueous solution

form

buffered aqueous solution

recombinant

expressed in Sf9 cells

recombinant

expressed in Sf9 cells

recombinant

-

recombinant

-

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Application

Phosphodiesterase 3B has been used in a study to evaluate the evidence for biological effects of metformin in operable breast cancer. Phosphodiesterase 3B has also been used in a study to investigate the role of intracellular and intercellular communication in perfusion distribution of erythrocyte-derived ATP.

Physical properties

N-terminal GST-tagged 86 kDa protein containing amino acids 592-end

Unit Definition

One unit will convert 1.0 picomole of 3′,5′-cAMP to 5′-AMP per minute at pH 7.4 at 37 °C.

Physical form

Buffered aqueous solution containing Tris-HCl (pH 8.0), NaCl, KCl, Tween-20, DTT, and glycerol

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Randy S Sprague et al.
Microcirculation (New York, N.Y. : 1994), 19(5), 430-439 (2012-07-11)
In complex organisms, both intracellular and intercellular communication are critical for the appropriate regulation of the distribution of perfusion to assure optimal O(2) delivery and organ function. The mobile erythrocyte is in a unique position in the circulation as it
Sirwan Hadad et al.
Breast cancer research and treatment, 128(3), 783-794 (2011-06-10)
Metformin may reduce the incidence of breast cancer and enhance response to neoadjuvant chemotherapy in diabetic women. This trial examined the effects of metformin on Ki67 and gene expression in primary breast cancer. Non-diabetic women with operable invasive breast cancer
Lin Xie et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 18(4), 444-454 (2011-12-14)
Here we examined whether the expression of a novel immunoregulatory gene set could be used to predict outcomes in murine models of rapamycin-induced cardiac tolerance, spontaneous hepatic tolerance, and cardiac rejection. The expression of the immunoregulatory gene set was assessed
Chimed Jansen et al.
Journal of medicinal chemistry, 56(5), 2087-2096 (2013-02-16)
Trypanosoma brucei cyclic nucleotide phosphodiesterase B1 (TbrPDEB1) and TbrPDEB2 have recently been validated as new therapeutic targets for human African trypanosomiasis by both genetic and pharmacological means. In this study we report the crystal structure of the catalytic domain of
N B Matveeva et al.
Biofizika, 57(5), 832-839 (2012-11-10)
Possible involvement of autocrine factors into the control of motile behavior via a receptor-mediated mechanism was investigated in Physarum polycephalum plasmodium, a multinuclear amoeboid cell with the auto-oscillatory mode of motility. Cyclic adenosine monophosphate (cAMP) and extracellular cAMP-specific phosphodiesterase, its

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