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ED2SC

Sigma-Aldrich

Ethylenediaminetetraacetic acid calcium disodium salt

Synonym(s):
EDTA calcium disodium salt, Edathamil, (Ethylenedinitrilo)tetraacetic acid calcium disodium salt
Linear Formula:
C10H12N2O8CaNa2
CAS Number:
Molecular Weight:
374.27
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

biological source

synthetic

assay

97.0-102.0% (titration)

form

powder

solubility

water: 1.6 g/10 mL, clear, colorless to faintly yellow

storage temp.

room temp

SMILES string

[Na+].[Na+].[Ca++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4

InChI key

SHWNNYZBHZIQQV-UHFFFAOYSA-J

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Application

Used to eliminate enzyme inhibition by traces of heavy metals, and to inhibit enzymes that require divalent cations as cofactors. As this form is already chelated with Ca2+, it is selective for divalent cations with greater affinity for EDTA, which it will exchange for Ca2+.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

More documents

Quotes and Ordering

Bénédicte Gnangnon et al.
Bio-protocol, 10(11), e3647-e3647 (2021-03-05)
The study of host/pathogen interactions at the cellular level during Plasmodium intra-erythrocytic cycle requires differential extraction techniques aiming to analyze the different compartments of the infected cell. Various protocols have been proposed in the literature to study specific compartments and/or
Matthew A Walker et al.
JCI insight, 6(3) (2021-02-09)
A hallmark of impaired myocardial energetics in failing hearts is the downregulation of the creatine kinase (CK) system. In heart failure patients and animal models, myocardial phosphocreatine content and the flux of the CK reaction are negatively correlated with the
Chelation therapy and cardiovascular outcomes.
Bruce Kleinman
JAMA, 310(4), 431-431 (2013-08-07)
Gervasio A Lamas et al.
JAMA, 309(12), 1241-1250 (2013-03-28)
Chelation therapy with disodium EDTA has been used for more than 50 years to treat atherosclerosis without proof of efficacy. To determine if an EDTA-based chelation regimen reduces cardiovascular events. Double-blind, placebo-controlled, 2 × 2 factorial randomized trial enrolling 1708
Evaluation of the Trial to Assess Chelation Therapy (TACT): the scientific process, peer review, and editorial scrutiny.
Howard Bauchner et al.
JAMA, 309(12), 1291-1292 (2013-03-28)

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