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G8634

Sigma-Aldrich

Guanosine 5′-[γ-thio]triphosphate tetralithium salt

≥90% (contains < 10% GDP, HPLC), powder

Synonym(s):

GTPγS tetralithium salt, GTP-γ-S-Li4, Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

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1 MG
$88.40
5 MG
$290.00
10 MG
$411.00
25 MG
$1,040.00

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1 MG
$88.40
5 MG
$290.00
10 MG
$411.00
25 MG
$1,040.00

About This Item

Empirical Formula (Hill Notation):
C10H12Li4N5O13P3S
CAS Number:
94825-44-2
Molecular Weight:
562.98
Beilstein/REAXYS Number:
8182249
EC Number:
305-606-1
MDL number:
MFCD00135151
UNSPSC Code:
41106305
PubChem Substance ID:
24895344
NACRES:
NA.77

$88.40

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Quality Level

200

assay

≥90% (contains < 10% GDP, HPLC)

form

powder

color

white to off-white

solubility

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

AMQXJFWJOAWCPV-ZVQJTLEUSA-J

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Application

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:
  • as a component of lysis buffer[1]
  • in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state[2]
  • to couple with G- protein α, to study its effect on kinase activity[3]

Biochem/physiol Actions

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000387141
0000376016
0000376018
0000376017
0000340487

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Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway
Sanchez BP, et al.
Cellular Signalling, 21(9), 1444-1454 (2009)
Rab27a is an essential component of melanosome receptor for myosin Va
Wu X, et al.
Molecular Biology of the Cell, 13(5), 1735-1749 (2002)
Matthew C Thibodeau et al.
The Journal of biological chemistry, 299(1), 102764-102764 (2022-12-05)
The formation of complexes between Rab11 and its effectors regulates multiple aspects of membrane trafficking, including recycling and ciliogenesis. WD repeat-containing protein 44 (WDR44) is a structurally uncharacterized Rab11 effector that regulates ciliogenesis by competing with prociliogenesis factors for Rab11
Jing Geng et al.
Nature communications, 12(1), 3519-3519 (2021-06-12)
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR4 signal-mediated innate
Chantal Binda et al.
The Journal of biological chemistry, 294(45), 16865-16883 (2019-10-03)
Accumulating evidence indicates that G protein-coupled receptors (GPCRs) interact with Rab GTPases during their intracellular trafficking. How GPCRs recruit and activate the Rabs is unclear. Here, we report that depletion of endogenous L-type prostaglandin D synthase (L-PGDS) in HeLa cells
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