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O7889

Sigma-Aldrich

Anti-OMP antibody produced in rabbit

~2 mg/mL, affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-Olfactory Marker Protein
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~19 kDa

species reactivity

rat, mouse

concentration

~2 mg/mL

technique(s)

western blot: 0.5-1.0 μg/mL using rat brain (olfactory bulb) extract (S1 fraction).

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Omp(24612)

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This Item
M7695M3319SAB4200606
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

mol wt

antigen ~19 kDa

mol wt

antigen ~66 kDa

mol wt

antigen 120 kDa

mol wt

antigen ~32 kDa

concentration

~2 mg/mL

concentration

-

concentration

-

concentration

~1.0 mg/mL

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General description

Olfactory marker protein (OMP) is a phylogenetically conserved cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. OMP is expressed in both the olfactory neuroepithelium and the olfactory nerve projection to the olfactory bulb. In perikaryon, OMP is produced and are transported to the dendrite and axon in the glomerular layer of the olfactory bulb.
Olfactory marker protein (OMP) is a phylogenetically conserved, 19kDa, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. The gene encoding OMP is localized on rat chromosome 1. OMP expression is initially detected in rat and mouse embryo during the last trimester of gestation and reaches adult levels at 2-4 weeks postnatally. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.

Immunogen

synthetic peptide corresponding to amino acids 119-137 located near the C-terminus of rat OMP conjugated to KLH.

Application

Anti-OMP antibody produced in rabbit has been used in immunohistochemistry.
Anti-OMP antibody produced in rabbit has been used in:
  • immunoblotting
  • double immunofluorescence
  • staining

Biochem/physiol Actions

Olfactory marker protein (OMP) helps to modulate the formation and refinement of the olfactory glomerular map. OMP-deficient mice generated by gene targeting in embryonic stem (ES) cells are compromised in their ability to respond to odor stimuli. In the OMP-null mouse, in addition to reduced odorant response, the levels of neural tyrosine hydroxylase (TH) and neuropeptide cholecystokinin (CCK) are severely reduced. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements.
Biochemistry, 44(28), 9673-9679 (2005)
Expression of CD36 by olfactory receptor cells and its abundance on the epithelial surface in mice
Lee S, et al.
PLoS ONE, 10(7), e0133412-e0133412 (2015)
Violaine Mechin et al.
Animals : an open access journal from MDPI, 13(12) (2023-06-28)
Chemical communication in mammals is ensured by exchanging chemical signals through the vomeronasal organ (VNO) and its ability to detect pheromones. The alteration of this organ has been proven to impact animal life, participating in the onset of aggressive behaviors
Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction.
Baldisseri DM,
Journal of Molecular Biology, 319(3), 823-837 (2002)
Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons.
Proceedings of the National Academy of Sciences of the USA, 93(18), 9858-9863 (1996)

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