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  • SML2272
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SML2272

Sigma-Aldrich

AZD-2098

≥98% (HPLC)

All Photos(1)
Synonym(s):
2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide, 2,3-Dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide, AZD 2098, AZD2098
Empirical Formula (Hill Notation):
C11H9Cl2N3O3S
CAS Number:
566203-88-1
Molecular Weight:
334.18
MDL number:
MFCD31382158
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O

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AZD-2098 ≥98% (HPLC)

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AZD2461 ≥98% (HPLC)

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SML1858

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Sigma-Aldrich

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SML2840

AZD2066

AZD6482 ≥98% (HPLC)

Sigma-Aldrich

SML2195

AZD6482

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Biochem/physiol Actions

AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ∼120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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