MilliporeSigma

The LXRs: a new class of oxysterol receptors.

Current opinion in genetics & development (1998-10-31)
D J Peet, B A Janowski, D J Mangelsdorf
ABSTRACT

The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping understand the function of these receptors in vivo and first suggested their role in the regulation of lipid metabolism. Confirmation of this role has come from the recent analysis of LXR-deficient mice, which has demonstrated the essential function of one of these receptors in the liver as a major sensor of dietary cholesterol.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
LXR β isoform, ligand binding domain (211-461), GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sigma-Aldrich
LXR, β isoform, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sigma-Aldrich
LXR, α human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sigma-Aldrich
LXR, α, ligand binding domain, GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sigma-Aldrich
LXR, β human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sigma-Aldrich
LXRα-ligand binding domain (215-667) human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sigma-Aldrich
LXR, α isoform, N-terminal region (1-182), GST tagged β human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sigma-Aldrich
LXR β-ligand binding domain (211-461) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sigma-Aldrich
LXR, α isoform, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)