• Home
  • Search Results
  • Efficacy of hydrocortisone in preventing posttraumatic stress disorder following critical illness and major surgery.

Efficacy of hydrocortisone in preventing posttraumatic stress disorder following critical illness and major surgery.

Annals of the New York Academy of Sciences (2006-08-08)
Gustav Schelling, Benno Roozendaal, Till Krauseneck, Martin Schmoelz, Dominique DE Quervain, Josef Briegel

Like other humans exposed to extreme trauma, patients who have been treated in an intensive care unit (ICU) often report traumatic memories. Extremely traumatic memories from the ICU in some of these patients are associated with the development of posttraumatic stress disorder (PTSD), which results in significant impairments in health-related quality of life (HRQL) outcomes of ICU therapy. Severely ill patients in the ICU often show insufficient endogenous glucocorticoid signaling, which has recently been termed critical illness-related corticosteroid insufficiency (CIRCI). We performed several controlled trials in ICU patients with suspected CIRCI from septic shock or cardiac surgery, which indicated that the administration of glucocorticoids (stress doses of hydrocortisone) during ICU treatment results in a significant reduction of PTSD symptoms in long-term survivors as well as improvements in HRQL outcomes. Stress doses of hydrocortisone could help to surmount impaired glucocorticoid signaling from CIRCI during critical illness resulting in a downregulation of the stress response as well as inhibition of traumatic memory retrieval and facilitated extinction of aversive information.

Product Number
Product Description

Hydrocortisone, BioReagent, suitable for cell culture
Hydrocortisone solution, 50 μM, sterile-filtered, BioXtra, suitable for cell culture
Hydrocortisone, ≥98% (HPLC)
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture
Cortisol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Hydrocortisone, Pharmaceutical Secondary Standard; Certified Reference Material
Hydrocortisone, United States Pharmacopeia (USP) Reference Standard
Hydrocortisone, meets USP testing specifications
Hydrocortisone, European Pharmacopoeia (EP) Reference Standard
Hydrocortisone for peak identification, European Pharmacopoeia (EP) Reference Standard
Hydrocortisone, VETRANAL®, analytical standard