21860

CDI

≥97.0% (T), for peptide synthesis

• Synonym(s): 1,1′-Carbonyldiimidazole
• Empirical Formula (Hill Notation): C₇H₆N₄O
• CAS Number: 530-62-1
• Molecular Weight: 162.15
• NACRES: NA.22
• PubChem Substance ID: 57647944
• UNSPSC Code: 12352115
• EC Number: 208-488-9
• MDL number: MFCD00005286
• Beilstein/REAXYS Number: 6826
• eCl@ss: 32150313

Properties

• Product Name: CDI, ≥97.0% (T)
• Quality Segment: 200
• assay: ≥97.0% (T)
• form: solid
• reaction suitability: reaction type: Carbonylations
• sustainability: Sustainability features
• mp: 115-122 °C, 117-122 °C (lit.)
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: O=C(n1ccnc1)n2ccnc2
• InChI: 1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H
• InChI key: PFKFTWBEEFSNDU-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Green Chemistry. 1,1′-carbonyldiimidazole (CDI) is an alternative to highly toxic insidious poison phosgene and thus aligns with the principle "Designing Safer Chemicals". Click here for more information.

CDI serves as a powerful coupling reagent in peptide synthesis and organic chemistry.

Application

CDI (1,1′-Carbonyldiimidazole) can be used:

• In the activation of malonic acid derivatives to prepare carbonyl imidazoles by mild decarboxylation.
• In the activation of cellulose membranes for the development of immunosensors.
• In the synthesis of substituted 1,3-oxazolo[4,5-d] pyridazinones.
• As a reagent for the conversion of various hydroxamic acids to isocyanates by Lossen rearrangement.
• In the synthesis of 1,3,4-oxadiazole derivatives , and peptide thioesters in water.
• As an acylation agent for the synthesis of carbamates.

Other Notes

Reactive reagent for the activation of acids as imidazolides: synthesis of esters, amides, ketones etc. Reagent for immobilizing enzymes and affinity ligands; Carbonyl-transfer reagent for the synthesis of various heterocycles, some recent applications

Safety Information

• Pictograms: GHS08,GHS05,GHS07
• Signal Word: Danger
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
• Hazard Codes: H302,H314,H360D
• Precautionary Statements: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects