If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
901558
Lenalidomide
≥95%
Synonym(s):
1-Oxo-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole, 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, E3 Ligase ligand, Ligand for PROTAC® research
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Available to ship TODAYfromMILWAUKEE | $61.60 |
1 g | Available to ship TODAYfromMILWAUKEE | $195.00 $146.25 |
5 g | Available to ship TODAYfromMILWAUKEE | $375.00 $281.25 |
About This Item
ligand
lenalidomide
assay
≥95%
form
powder
reaction suitability
reagent type: ligand
technique(s)
targeted protein degradation: suitable
mp
265-268 °C
storage temp.
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
InChI
1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChI key
GOTYRUGSSMKFNF-UHFFFAOYSA-N
Application
.
Other Notes
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins
Legal Information
1 of 1
This Item | |||
|---|---|---|---|
| description ≥95% | description ≥98% (HPLC) | description ≥95% | description - |
| assay ≥95% | assay ≥98% (HPLC) | assay ≥95% | assay - |
| form powder | form powder | form powder | form solid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| reaction suitability reagent type: ligand | reaction suitability reagent type: ligand | reaction suitability reagent type: ligand | reaction suitability reagent type: ligand-linker conjugate, reactivity: carboxyl reactive |
| ligand lenalidomide | ligand lenalidomide | ligand C5 Lenalidomide | ligand C5 Lenalidomide |
| mp 265-268 °C | mp - | mp - | mp - |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Repr. 1B - STOT RE 2
Target Organs
Blood
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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