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Technical Webinars

More Success in LC-MS – Tips and Tricks for Sample & Mobile Phase Preparation and Column Selection


Date: Thursday, November 15, 2018

Time: 11:00 AM (Eastern Time)

Duration: 60 minutes


What Does It Cover?

LC-MS is one of the most commonly used analytical techniques in various sectors for quantitation and identification of unknown from variety of complex samples. Use of LC-MS has expanded over the years as it offers both selectivity and specificity in analysis. With advances in both chromatography and mass spectrometry, sensitivity and accuracy of this technique has further increased, allowing for detection and identification of low-level analytes in complex sample matrices.

The LC-MS workflow has three main components, which determine successful analyses: sample preparation, choice of mobile phase components and column selection. Not paying enough attention to one of these components can complicate data analysis, quantitation and identification.

In this seminar, you will learn critical factors to consider when selecting the sample preparation methods, mobile phase components and HPLC columns.

 What Will You Learn?

 We will discuss:

  • Different sample preparation methods and their effect on sample clean up (particle removal, analyte binding, and extractables)
  • Quality of mobile phase components (solvents, water and buffer salts) and their impact on background signal in LC-MS analysis
  • HPLC column selection
  • Useful tips to improve overall chromatography performance

 Who Should Attend?

Scientists, technicians, PIs who use LC-MS and HPLC in drug development, pharmaceutical, proteomics, food analysis, environmental applications.


Featured Articles


Sigma-Aldrich Technical Article

LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Antibody-drug conjugates (ADC) represent a rapidly emerging class of biotherapeutic molecules, which harness the specificity of monoclonal antibodies (mAb) to selectively deliver highly potent cytotoxic drugs. Like all biotherapeutics they require significant analytical characterization. A non-toxic ADC surrogate, or “ADC Mimic,” with highly similar physicochemical properties to commercial ADCs provides an excellent molecule to safely drive analytical method development . . .

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Supelco Reporter

Accelerated Bioanalytical LC/MS/MS Using Ascentis Express

Fast bioanalysis requires the use of short columns packed with high efficiency particles. The use of HPLC columns packed with Fused-Core® particles and sub-2 μm porous particles have led the way in these demanding analyses. They significantly enhance resolution and speed by producing either higher efficiency for the same column length or equivalent efficiency with a shorter column length. The use of ultra-high performance liquid chromatography (UHPLC) comes at a price of much higher pressure when sub-2 μm particles are employed. . .

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Supelco Technical Article

3S Reagents for Volumetric Titration

Connect Your Lab
3S is an intelligent packaging solution protected with an originality seal. The cap provides information via Radio-frequency identification or RFID, enabling automated data transfer between the reagent and titration instrument. Intelligent communication for improved performance.

Titration on a new level—wet chemical analysis is made safer and more reliable by 3S Adapter Technology:

Safe chemical handling: minimized risk of contamination through contact-free reagent exchange

Smart connection of chemical consumables: communication between the 3S cap and instrument software via RFID . . .