Pharma Analysis & QC


Trust our HPLC Columns, Solvents, Reagents, Standards, Filtration products and LC-MS workflow at any stage of your method development and validation. Whether it is ADME/DMPK, Drug Product Formulation, API Stability, Impurity Profiling, Dissolution Testing or USP/EP Monograph testing, we have the expertise to help you feel better about your small molecule, peptide, protein, mAbs, ADCs, or excipient analysis.

 

 

Technical Webinars

Simplifying High-Throughput Pharmacokinetic LC-MS Analysis of Monoclonal Antibodies

Wednesday, September 26, 2018 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST

This webcast provides insights to a new method for pharmacokinetics analysis. This method provides a robust and high-throughput approach for quantification of human IgG1 antibodies in animal sera by LC–MS/MS in a 96-well plate based format. This approachis designed for preclinical quantification of monoclonal antibodies (mAbs). Key benefits of the approach include:

  • It is four times faster than current methods
  • It requires only 5 mL of sample vs 25–100 mL in other methods

Register Here

 

Featured Articles

 

Sigma-Aldrich Technical Article

LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Antibody-drug conjugates (ADC) represent a rapidly emerging class of biotherapeutic molecules, which harness the specificity of monoclonal antibodies (mAb) to selectively deliver highly potent cytotoxic drugs. Like all biotherapeutics they require significant analytical characterization. A non-toxic ADC surrogate, or “ADC Mimic,” with highly similar physicochemical properties to commercial ADCs provides an excellent molecule to safely drive analytical method development . . .

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Supelco Reporter

Accelerated Bioanalytical LC/MS/MS Using Ascentis Express

Fast bioanalysis requires the use of short columns packed with high efficiency particles. The use of HPLC columns packed with Fused-Core® particles and sub-2 μm porous particles have led the way in these demanding analyses. They significantly enhance resolution and speed by producing either higher efficiency for the same column length or equivalent efficiency with a shorter column length. The use of ultra-high performance liquid chromatography (UHPLC) comes at a price of much higher pressure when sub-2 μm particles are employed. . .

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Supelco Technical Article

The Importance of the Standardization of Volumetric Solutions

The so-called titer determination or standardization of a volumetric solution used for titration is one of the most important preconditions for reliable and transparent titration results. Accurate and reliable titration results are only achievable when we work with the exact concentration of the volumetric solution. . .

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