ALD00613
PSI2
Synonym(s):
Ψ2, 2-(Perfluorophenoxy)-1,3,2-dithiaphospholane 2-sulfide, Achiral phosphorus-sulfur Incorporation reagent
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| Size/SKU | Availability | Price |
|---|---|---|
500 mg | 1 left in stock | $165.00 |
5 g | Available to ship TODAY | $873.00 |
25 g | Available to ship TODAY | $1,500.00 |
About This Item
Empirical Formula (Hill Notation):
C8H4F5OPS3
Molecular Weight:
338.28
NACRES:
NA.22
UNSPSC Code:
12352005
Application
PSI2 is a stable and sustainably prepared P(V) reagent developed by the Baran Lab for the synthesis of phosphorodithioate oligonucleotides. The phosphorodithioate linkages afforded by PSI2 are effectively cleaved by RNAse-H while remaining stable to nucleases, and can be formed rapidly in high yield. The synthetic methodology accessed by PSI2 and other PSI reagents (see ALD00602 and ALD00604) allows at will installation of a greater diversity of linkages to DNA and other nucleotides with comparable performance to existing state-of-the-art P(III) based reagents. The resulting compounds have applications in gene-based therapeutics such as antisense oligonucleotides (ASOs).
Learn more about PI and PSI reagents
Learn more about PI and PSI reagents
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This Item | |||
|---|---|---|---|
| description - | description 95% | description 95% | description ≥95% |
| form powder | form powder or crystals | form powder or crystals | form powder |
| mp 94-97 °C | mp 102-107 °C | mp 103-107 °C | mp 118-123 °C |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 100 |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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