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R5010

Resveratrolo

≥99% (HPLC)

Sinonimo/i:

3,4′,5-triidrossi-trans-stilbene, 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol

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A voi/SKUDisponibilitàPrezzo
100 mg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
244,00 €
500 mg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
973,00 €

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C14H12O3
Numero CAS:
501-36-0
Peso molecolare:
228.24
NACRES:
NA.25
PubChem Substance ID:
24278055
UNSPSC Code:
12352205
MDL number:
MFCD00133799

244,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
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biological source

plant root (bushy knotweed)

Quality Segment

200

assay

≥99% (HPLC)

form

powder

solubility

acetone: 50 mg/mL, clear, faintly yellow

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

Oc1ccc(cc1)\C=C\c2cc(O)cc(O)c2

InChI

1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+

InChI key

LUKBXSAWLPMMSZ-OWOJBTEDSA-N

Gene Information

human ... AR(367), CYP1A2(1544), ESR1(2099), SIRT1(23411)
mouse ... Nos2(18126)
rat ... Esr1(24890)

Application

Inibitore selettivo della COX−1.
Il resveratrolo è stato utilizzato:
  • in esperimenti sull′intrappolamento
  • per studiare il suo effetto neuroprotettivo sulla morte delle cellule neuronali retiniche che viene mediata dall′attivazione della protein-chinasi II dipendente da Ca2+/calmodulina indotta dal diabete
  • come standard nella valutazione del contenuto di stilbene nelle foglie di vite mediante fluorometria in vivo

Biochem/physiol Actions

Il resveratrolo è una fitoalessina fenolica presente nella buccia d′uva e in altre piante. Esercita un′attività antiossidante intracellulare e attiva la sirtuina 1 (SIRT1), un′istone deacetilasi dipendente dal nicotinammide adenina dinucleotide (NAD+) coinvolta nella biogenesi mitocondriale e nella promozione dell′attività del coattivatore-1a del recettore g-attivato dei proliferatori dei perossisomi (PGC-1a) e di FOXO (forkhead box). Le azioni anti-diabetiche, neuroprotettive e anti-adipogeniche del resveratrolo possono essere mediate tramite l′attivazione della SIRT1. Il resveratrolo svolge un′azione antivirale contro il virus dell′Herpes simplex-1 (HSV1) e HSV2. Mostra inoltre attività biologiche antitumorali e fitoestrogeniche. Il resveratrolo è noto per la sua capacità di prolungare la vita in molte specie tramite la mediazione di diversi eventi fisiologici.

Preparation Note

Solubile in etanolo, DMSO e acetone. Solo lievemente solubile in acqua (3 mg/100 mL).

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Questo articolo
34092554325PHR2201
Resveratrolo ≥99% (HPLC)

Sigma-Aldrich

R5010

Resveratrolo

Resveratrolo analytical standard

Supelco

34092

Resveratrolo

Resveratrol A phenolic product found in both grape skins and wines.

Sigma-Aldrich

554325

Resveratrol

Resveratrolo Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2201

Resveratrolo

assay

≥99% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

form

powder

form

-

form

solid

form

-

biological source

plant root (bushy knotweed)

biological source

-

biological source

-

biological source

-

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

cleaning products
cosmetics
food and beverages
personal care

application(s)

-

application(s)

pharmaceutical small molecule

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

acetone: 50 mg/mL, clear, faintly yellow

solubility

-

solubility

DMSO: 50 mg/mL

solubility

-

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Classe di stoccaggio

11 - Combustible Solids

flash_point_f

>392.0 °F - closed cup - (External MSDS)

flash_point_c

> 200.0 °C - closed cup - (External MSDS)

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

hcodes

H412

Hazard Classifications

Aquatic Chronic 3

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Domande

1–10 di 11 domande  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Utile?

  2. Can a resveratrol solution turn red?

    1 risposta

    1. Solubility is tested in acetone, resulting in a faint yellow color. In acidic conditions, resveratrol can appear more reddish. In neutral or alkaline conditions, resveratrol will appear yellowish or colorless. Oxidation of resveratrol may also change its color, potentially leading to a reddish hue. Resveratrol is highly oxidizable and reacts readily with reactive oxygen species.

      Utile?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile?

  4. What is the solubility limit in ethanol ?

    1 risposta

    1. This product is tested for solubility in acetone at 50 mg/mL. It is soluble in ethanol at 50 mg/mL and in DMSO at 16 mg/mL.

      Utile?

  5. does it expires? How long does powder last?

    1 risposta

    1. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

      Utile?

  6. 1- What is the iso-form (Cis or Trans) of the Resveratrol product R5010-500MG? 2- Do you have it emission spectra in 2-propanol and DMSO?

    1 risposta

    1. As per the IUPAC name given, this product is a trans isoform. Unfortunately, emission spectra in 2-propanol and DMSO cannot be provided.

      Utile?

  7. What is the Department of Transportation shipping information for this product?

    1 risposta

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Utile?

  8. In what applications do researchers use Resveratrol, Product R5010?

    1 risposta

    1. There are numerous applications for Resveratrol.  Several references indicate that it is used as a COX-1 inhibitor and a tumor repressor.

      Utile?

  9. How do I store Resveratrol, Product R5010, once in solution?

    1 risposta

    1. A 5 mM solution of R5010 in ethanol has been found to be stable for 12 weeks when stored at 2-8°C and protected from light.Given a molecular weight of 228.24, a 5 mM solution is approximately 1.1 mg/mL.Reference: D.M. Goldberg, et al., J. Chrom. A, 708, 89-98 (1995).

      Utile?

  10. How do I dissolve Resveratrol, Product R5010?

    1 risposta

    1. We test the solubility in ethanol at a concentration of 50 mg/mL.  It is also soluble at 16 mg/mL in DMSO (with sonication). It is practically insoluble in water.

      Utile?

1–10 di 11 domande  

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