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R5010

Resvératrol

≥99% (HPLC)

Synonyme(s) :

3,4′,5-trihydroxy-trans-stilbène, 5-[(1E)-2-(4-hydroxyphényl)éthényl]-1,3-benzènediol

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À vous/RéférenceDisponibilitéPrix
100 mg

Disponible dès aujourd'huiDeSt QuentinFallavier

244,00 €
500 mg

Disponible dès aujourd'huiDeSt QuentinFallavier

975,00 €

A propos de cet article

Formule empirique (notation de Hill) :
C14H12O3
Numéro CAS:
Poids moléculaire :
228.24
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:

244,00 €


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biological source

plant root (bushy knotweed)

Quality Segment

assay

≥99% (HPLC)

form

powder

solubility

acetone: 50 mg/mL, clear, faintly yellow

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

Oc1ccc(cc1)\C=C\c2cc(O)cc(O)c2

InChI

1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+

InChI key

LUKBXSAWLPMMSZ-OWOJBTEDSA-N

Gene Information

Application

Inhibiteur sélectif des COX−1.
Le resvératrol a été utilisé :
  • dans une expérience de piégeage
  • pour étudier son effet neuroprotecteur sur la mort des cellules neuronales rétiniennes induite par l'activation de la protéine kinase II activation dépendante du complexe Ca2+/calmoduline au cours du diabète
  • comme étalon pour l'évaluation de la teneur en stilbène des feuilles de vigne par fluorimétrie in vivo

Biochem/physiol Actions

Le resvératrol est une phytoalexine phénolique présente dans la pellicule des raisins ainsi que dans d'autres végétaux. Il présente une activité antioxydante intracellulaire et active la sirtuine 1 (SIRT1), histone désacétylase dépendante du nicotinamide adénine dinucléotide (NAD+) impliquée dans la biogenèse mitochondriale, dans l'activation du coactivateur 1α des récepteurs γ activés par les proliférateurs des peroxysomes (PGC-1α) et dans l'augmentation de l'activité des facteurs FOXO (domaine Forkhead). Les actions antidiabétique, neuroprotectrice et antiadipogénique du resvératrol peuvent dépendre de l'activation de la protéine SIRT1. Le resvératrol possède une action antivirale contre les virus Herpes simplex 1 et 2 (HSV1 et HSV2). Il présente également des activités biologiques phytoestrogénique et antitumorale. Le resvératrol est connu pour prolonger la vie de nombreuses espèces en intervenant dans plusieurs processus physiologiques.

Preparation Note

Soluble dans l'éthanol, le diméthylsulfoxyde et l'acétone. Très peu soluble dans l'eau (3 mg/100 ml).

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Cet article
Y000119434092554325
Resvératrol European Pharmacopoeia (EP) Reference Standard

Y0001194

Resvératrol

description

≥99% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

description

analytical standard

description

A phenolic product found in both grape skins and wines.

form

powder

form

-

form

-

form

solid

biological source

plant root (bushy knotweed)

biological source

-

biological source

-

biological source

-

assay

≥99% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

Quality Level

200

Quality Level

-

Quality Level

100

Quality Level

100

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
food and beverages
personal care

application(s)

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C


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Classe de stockage

11 - Combustible Solids

flash_point_f

>392.0 °F - closed cup - (External MSDS)

flash_point_c

> 200.0 °C - closed cup - (External MSDS)

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

hcodes

Hazard Classifications

Aquatic Chronic 3



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Questions

1–10 sur 11 questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. Can a resveratrol solution turn red?

    1 réponse
    1. Solubility is tested in acetone, resulting in a faint yellow color. In acidic conditions, resveratrol can appear more reddish. In neutral or alkaline conditions, resveratrol will appear yellowish or colorless. Oxidation of resveratrol may also change its color, potentially leading to a reddish hue. Resveratrol is highly oxidizable and reacts readily with reactive oxygen species.

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  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  4. What is the solubility limit in ethanol ?

    1 réponse
    1. This product is tested for solubility in acetone at 50 mg/mL. It is soluble in ethanol at 50 mg/mL and in DMSO at 16 mg/mL.

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  5. does it expires? How long does powder last?

    1 réponse
    1. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

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  6. 1- What is the iso-form (Cis or Trans) of the Resveratrol product R5010-500MG? 2- Do you have it emission spectra in 2-propanol and DMSO?

    1 réponse
    1. As per the IUPAC name given, this product is a trans isoform. Unfortunately, emission spectra in 2-propanol and DMSO cannot be provided.

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  7. In what applications do researchers use Resveratrol, Product R5010?

    1 réponse
    1. There are numerous applications for Resveratrol.  Several references indicate that it is used as a COX-1 inhibitor and a tumor repressor.

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  8. How do I dissolve Resveratrol, Product R5010?

    1 réponse
    1. We test the solubility in ethanol at a concentration of 50 mg/mL.  It is also soluble at 16 mg/mL in DMSO (with sonication). It is practically insoluble in water.

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  9. What is the Department of Transportation shipping information for this product?

    1 réponse
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  10. How do I store Resveratrol, Product R5010, once in solution?

    1 réponse
    1. A 5 mM solution of R5010 in ethanol has been found to be stable for 12 weeks when stored at 2-8°C and protected from light.Given a molecular weight of 228.24, a 5 mM solution is approximately 1.1 mg/mL.Reference: D.M. Goldberg, et al., J. Chrom. A, 708, 89-98 (1995).

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