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Anti-Cathepsin D antibody, Mouse monoclonal

Name: Anti-Cathepsin D antibody, Mouse monoclonal
Brand: SIGMA
Price: 453.9 USD
Availability: InStock

clone CTD-19, purified from hybridoma cell culture

Synonym(s):

Anti-CTSD, cleaved into the following 2 chains: Cathepsin D light chain and Cathepsin D heavy chain

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100 μL	Check Cart for Availability	$534.00 $453.90

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

CTD-19, monoclonal

Application:

IF, IHC

Citations:

$453.90

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Properties

biological source

mouse

Quality Segment

300

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

CTD-19, monoclonal

form

buffered aqueous solution

species reactivity

human, rabbit

concentration

~1.0 mg/mL

technique(s)

immunoblotting: 2-4 μg/mL using human breast cancer MCF7 cell line, immunofluorescence: 5-10 μg/mL using HeLa cells, immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human liver sections

isotype

IgG2a

UniProt accession no.

P07339

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CTSD(1509)

Description

General description

Anti-Cathepsin D antibody, Mouse monoclonal (mouse IgG2a isotype) is derived from the CTD-19 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with cathepsin D purified from human liver. Cathepsin D (CatD or CTSD) is synthesized in the rough endoplasmic reticulum as pre-proprotein. After removal of signal peptide, the pro-CatD is targeted to endosomes to form an active, ~48 kDa, single-chain intermediate then to the lysosomes to form the fully active mature protease, composed of a ~30 kDa heavy chain and a ~14 kDa light chain.

Immunogen

Cathepsin D Purified from human liver

Application

Anti-Cathepsin D antibody, Mouse monoclonal has been used in:

immunoblotting
immunohistochemistry
immunofluorescence

Biochem/physiol Actions

CatD plays numerous physiological functions in the cells including metabolic degradation of intracellular proteins and the activation of enzymatic precursors. In the central nervous system, CatD is particularly important for the control of neuronal homeostasis, cell migration and interneuron communication. CatD-mediated proteolysis mediates the degradation of unfolded/oxidized protein aggregates in lysosome. The level of CatD synthesized by the cells is increased in response to mitogenic signals from estrogen, epidermal growth factor (EGF), fibroblast growth factor (FGF), and insulin like growth factor-I (IGF- I). The ability of tumor cells to invade the extracellular matrix has been attributed to cathepsins released by tumor cells or associated with its plasma membrane.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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This Item	C0715	C4618	SAB4200717
Sigma-Aldrich SAB4200767 Anti-Cathepsin D antibody, Mouse monoclonal	Sigma-Aldrich C0715 Monoclonal Anti-Cathepsin D antibody produced in mouse	Sigma-Aldrich C4618 Monoclonal Anti-Cathepsin L antibody produced in mouse	Sigma-Aldrich SAB4200717 Anti-Troponin T antibody, Mouse monoclonal
description clone CTD-19, purified from hybridoma cell culture	description clone CTD-19, ascites fluid	description clone CPL33/1, purified from hybridoma cell culture	description clone JLT-12, purified from hybridoma cell culture
clone CTD-19, monoclonal	clone CTD-19, monoclonal	clone CPL33/1, monoclonal	clone JLT-12, monoclonal
Gene Information human ... CTSD(1509)	Gene Information human ... CTSD(1509)	Gene Information human ... CTSL1(1514)	Gene Information human ... TNNT1(7138)
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity human, rabbit	species reactivity human	species reactivity human	species reactivity rat, human, mouse, bovine, rabbit, goat
biological source mouse	biological source mouse	biological source mouse	biological source mouse
antibody form purified from hybridoma cell culture	antibody form ascites fluid	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c