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Anti-Human IgG3-Peroxidase antibody, Mouse monoclonal

Name: Anti-Human IgG3-Peroxidase antibody, Mouse monoclonal
Brand: SIGMA
Price: 402.05 USD
Availability: InStock

clone HP-6050, purified from hybridoma cell culture

Synonym(s):

Anti-Human immunoglobulin G3

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1 vial	Estimated to ship TODAYfromMILWAUKEE	$473.00 $402.05

About This Item

NACRES:

NA.46

UNSPSC Code:

12352203

Conjugate:

peroxidase conjugate

Clone:

HP-6050, monoclonal

Application:

ELISA (d)

Citations:

$402.05

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Properties

biological source

mouse

Quality Segment

200

conjugate

peroxidase conjugate

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

HP-6050, monoclonal

form

lyophilized powder

species reactivity

human

concentration

~2 mg/mL

technique(s)

direct ELISA: 1:80,000-1:160,000 using 2 μg/mL human IgG3 for coating.

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Description

General description

Human IgG consist of four subclasses (1-4) that can be recognized by the antigenic difference in their heavy chains. They constitute approximately 65, 30, 5 and 4% of the total IgG, respectively. Each subclass has different biological and physiochemical properties. The IgG subclass may be preferentially produced in response to different antigens and pathological conditions. For instance, anti-polysaccharide responses are mainly of the IgG2 subclass while protein antigens responses give rise to IgG1 and IgG3 antibodies. IgG1 and IgG3 are the only subclasses capable of adherence to mononuclear phagocytes and are recognized readily by the Fc receptors on various reticulo-endothelial cells, while IgG2 and IgG4 are far less efficient. The abundance of the different IgG subclasses in the bloodstream varies with age, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels rise more slowly, reaching adult levels at about 10 years of age. Serum IgG subclass deficiencies have been recorded for different patient groups. IgG3 deficiency has been associated with a patient′s history of recurrent infectious that may lead to chronic lung disease. Decreased IgG3 levels are frequently associated with IgG1 deficiency. Examination of the distribution pattern of IgG subclasses in different types of diseases may provide insight into the related immunological processes and may assist in the diagnosis of various disorders.

Immunogen

Human IgG3 myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads

Application

Direct ELISA: a working dilution of 1:80,000-1:160,000 is recommended using 2 μg/mL human IgG3 for coating.

Physical form

Supplied as a lyophilized powder.

Other Notes

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

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Show Differences

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This Item	SAB4200768	SAB4200770	SAB4200788
Sigma-Aldrich SAB4200769 Anti-Human IgG3-Peroxidase antibody, Mouse monoclonal	Sigma-Aldrich SAB4200768 Anti-Human IgG1-Peroxidase antibody, Mouse monoclonal	Sigma-Aldrich SAB4200770 Anti-Human IgG4-Peroxidase antibody, Mouse monoclonal	Sigma-Aldrich SAB4200788 Anti-Human IgG1 (Fc specific) antibody, Mouse monoclonal
description clone HP-6050, purified from hybridoma cell culture	description clone 8c/6-39, purified from hybridoma cell culture	description clone HP-6025, purified from hybridoma cell culture	description clone HP-6001, purified from hybridoma cell culture
species reactivity human	species reactivity human	species reactivity human	species reactivity human
clone HP-6050, monoclonal	clone 8c/6-39, monoclonal	clone HP-6025, monoclonal	clone HP-6001, monoclonal
conjugate peroxidase conjugate	conjugate peroxidase conjugate	conjugate peroxidase conjugate	conjugate -
biological source mouse	biological source mouse	biological source mouse	biological source mouse
antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

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Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H317

Precautionary Statements

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

WGK

WGK 1

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