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T101

Gaboxadol hydrochloride

solid, ≥98% (HPLC)

Synonym(s):

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride, THIP hydrochloride

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAY

$152.00
100 mg

Available to ship TODAY

$261.00
500 mg

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$834.00

About This Item

Empirical Formula (Hill Notation):
C6H8N2O2 · HCl
CAS Number:
Molecular Weight:
176.60
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
285-687-7
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$152.00


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Quality Segment

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

ethanol: 0.91 mg/mL, H2O: 20 mg/mL

SMILES string

Cl[H].Oc1noc2CNCCc12

InChI

1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H

InChI key

ZDZDSZQYRBZPNN-UHFFFAOYSA-N

General description

Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.

Application

Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.

Biochem/physiol Actions

GABAA receptor agonist.

Disclaimer

Photosensitive

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This Item
P9159G002G019
description

solid, ≥98% (HPLC)

description

-

description

solid

description

≥98% (HPLC), solid

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

solubility

ethanol: 0.91 mg/mL, H2O: 20 mg/mL

solubility

-

solubility

H2O: soluble (refrigerate if not used immediately.), neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily), methanol: slightly soluble

solubility

H2O: >10 mg/mL

form

solid

form

powder

form

solid

form

solid

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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