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Congo Red, High Purity

Name: Congo Red, High Purity
Brand: MM
Price: 116 USD
Availability: InStock

An amyloidophylic dye that specifically stains stacked β sheet aggregates.

Synonym(s):

Congo Red, High Purity, 3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na

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Size/SKU	Availability	Price
500 mg	Check Cart for Availability	$116.00

About This Item

Empirical Formula (Hill Notation):

C₃₂H₂₂N₆O₆S₂ · 2Na

CAS Number:

573-58-0

Molecular Weight:

696.66

UNSPSC Code:

12171500

NACRES:

NA.25

MDL number:

MFCD00004028

$116.00

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Properties

Quality Segment

100

description

Merck USA index - 14, 2498

assay

≥75% dye basis

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

rust

solubility

water: 10 mg/mL, ethanol: soluble

shipped in

ambient

storage temp.

15-25°C

SMILES string

[Na+].[Na+].[S](=O)(=O)([O-])c1c2c(c(c(c1)N=Nc3ccc(cc3)c4ccc(cc4)N=Nc5c(c6c(c(c5)[S](=O)(=O)[O-])cccc6)N)N)cccc2

InChI

1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2

InChI key

IQFVPQOLBLOTPF-UHFFFAOYSA-L

Description

General description

An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.

Biochem/physiol Actions

Cell permeable: no

Primary Target
An amyloidophylic dye that specifically stains stacked β sheet aggregates

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).

Other Notes

Altschuler, S.E., et al. 2012. Biochemistrin press.
Khurana, R., et al. 2001. J. Biol. Chem.276, 22715.
Fezoui, Y., et al. 2000. Amyloid7, 166.
Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095.
Kramport, M., et al. 2000. Chem. Biol.7, 855.
Kuner, P., et al. 2000. J. Biol. Chem.275, 1673.
Caspi, S., et al. 1998. J. Biol. Chem.273, 3484.
Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768.
Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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1 of 1

This Item	C6277	C6767	75768
Sigma-Aldrich 234610 Congo Red, High Purity	Sigma-Aldrich C6277 Congo Red	Sigma-Aldrich C6767 Congo Red	Supelco 75768 Congo Red
description An amyloidophylic dye that specifically stains stacked β sheet aggregates.	description certified by the BSC, BioXtra	description Dye content ≥35 %	description analytical standard
color rust	color -	color red-brown	color -
solubility water: 10 mg/mL, ethanol: soluble	solubility H₂O: 10 mg/mL	solubility H₂O: 1 mg/mL	solubility -
form crystalline solid	form powder	form powder	form -
shipped in ambient	shipped in -	shipped in -	shipped in -
assay ≥75% dye basis	assay -	assay -	assay ≥97.0% (HPLC)
storage temp. 15-25°C	storage temp. room temp	storage temp. room temp	storage temp. -

pictograms

GHS08

signalword

Danger

hcodes

H350,H361d

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 1B - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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