This product is stored refrigerated at 2-8°C and assigned a lot-specific retest date of approximately 7 years from the date of Quality Release. Products that, while considered stable, may be subject to degradation over time are assigned a periodic retest date to confirm quality. The lot-specific retest date is reported on the Certificate of Analysis. Please see the link below to review a lot-specific Certificate:
https://www.sigmaaldrich.com/product/mm/3301#product-documentation
3301
17β-Estradiol
≥97% (HPLC), solid, estrogenic hormone, Calbiochem
17β-Estradiol
Synonym(s):
17β-Estradiol, 17 beta Estradiol
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Check Cart for Availability | $91.20 |
About This Item
Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
Molecular Weight:
272.38
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (by assay)
Form:
solid
Storage condition:
OK to freeze
Product Name
17β-Estradiol, Most potent mammalian estrogenic hormone.
Quality Segment
description
RTECS - KG2975000
Merck USA index - 14, 3703
assay
≥97% (by assay)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to off-white
solubility
ethanol: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
O[C@@H]1[C@@]2([C@H]([C@H]3[C@H](CC2)c4c(cc(cc4)O)CC3)CC1)C
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChI key
VOXZDWNPVJITMN-ZBRFXRBCSA-N
General description
17β-Estradiol is a potent estrogen, a steroid hormone, involved in reproductive and endocrine functions in mammals. It binds to estrogen receptors (ERα and ERβ) to regulate gene expression, influencing reproductive functions such as the proliferation of the uterine endometrium, ovulation, and maintenance of pregnancy. Additionally, 17β-Estradiol is involved in modulating metabolic processes, including lipid metabolism and insulin sensitivity, and exerts neuroprotective effects in the central nervous system.
Application
17β-Estradiol has been used to treat primary rat cortical neurons, to investigate its effects on neuronal responses to interleukin (IL)-6 and soluble IL-6 receptor treatment. It has also been administered subcutaneously to ovariectomized female mice to investigate its effects on Crhr1 and Esr1 mRNA expression in the nucleus accumbens.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
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This Item | |||
|---|---|---|---|
| description Most potent mammalian estrogenic hormone. | description - | description ≥98% | description BioReagent, powder, suitable for cell culture |
| form solid | form powder | form powder | form powder |
| assay ≥97% (by assay) | assay ≥98.00% (TLC) | assay ≥98% | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. room temp |
| storage condition OK to freeze | storage condition - | storage condition - | storage condition - |
signalword
Danger
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - ED ENV 1 - ED HH 1 - Lact. - Repr. 1A
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How long can it be stored in delivered dry form and what storage conditions are optimal.
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how long can you store the product at 4C after dissolving the product in ethanol ?
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When stored refrigerated at 2 - 8°C, de-gassed stock solutions are stable for up to 6 months. Alternatively, stock solutions may be stored frozen at -20°C for up to 3 months. Avoid repeated freeze/thaw cycles.
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