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8.22288
Periodic acid
for synthesis
Synonym(s):
Periodic acid
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| Size/SKU | Availability | Price |
|---|---|---|
100 g | Estimated to ship onAugust 31, 2026 | $158.00 |
500 g | Estimated to ship onSeptember 01, 2026 | $467.00 |
About This Item
Empirical Formula (Hill Notation):
H5IO6
CAS Number:
Molecular Weight:
227.94
UNSPSC Code:
12352301
EC Index Number:
233-937-0
NACRES:
NA.22
MDL number:
Assay:
≥98% (iodometric)
Form:
solid
Grade:
synthesis grade
grade
synthesis grade
Quality Segment
assay
≥98% (iodometric)
form
solid
reaction suitability
reagent type: oxidant
pH
1.2 (20 °C, 100 g/L in H2O)
mp
122 °C
solubility
ethanol: soluble at 20 °C, water: soluble at 20 °C
bulk density
1400 kg/m3
storage temp.
15-25°C
SMILES string
[I](=O)(O)(O)(O)(O)O
InChI
1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)
InChI key
TWLXDPFBEPBAQB-UHFFFAOYSA-N
Application
Periodic acid can be used as a reagent for the oxidative cleavage of 1,2 diols to ketones or aldehydes, and epoxides to aldehydes. It is also used in the oxidative cleavage of various protecting groups such as acetonide, tetrahydropyranyl ether (THP), ethoxyethyl acetals, cyclic acetals, dithioacetals, and oxathioacetals.
It can also be used:
It can also be used:
- In the selective N-nitrosation of secondary amines in the presence of sodium nitrite, and wet silica gel.
- As a stoichiometric oxidant with chromium (IV) acetate for the oxidation of tertiary C−H bonds to tertiary alcohols.
- In combination with chromium oxide to oxidize primary alcohols to carboxylic acids; alkylbenzenes to benzoic acids; and cyclic benzyl ethers to the corresponding lactones.
- In the iodination of bulky polyalkyl benzenes in the presence of iodine.
- In the oxidative coupling of polycyclic aromatic hydrocarbons in the presence of aqueous acetic acid.
- In the selective oxidation of sulfides to sulfoxides using FeCl3 as a catalyst.
Analysis Note
Assay (iodometric): ≥ 98.0 %
Melting range (lower value): ≥ 124 °C
Melting range (upper value): ≤ 129 °C
Melting range (lower value): ≥ 124 °C
Melting range (upper value): ≤ 129 °C
1 of 1
This Item | |||
|---|---|---|---|
| description for synthesis | description ReagentPlus®, ≥99.0% | description suitable for electrophoresis, ≥99% | description SAJ special grade, ≥98.5% |
| grade synthesis grade | grade - | grade electrophoresis grade | grade SAJ special grade |
| assay ≥98% (iodometric) | assay ≥99.0% | assay ≥99% | assay ≥98.5% |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level - |
| form solid | form powder or crystals | form powder or crystals | form crystalline |
| storage temp. 15-25°C | storage temp. - | storage temp. - | storage temp. - |
| solubility ethanol: soluble at 20 °C, water: soluble at 20 °C | solubility water: 100 mg/mL, clear, colorless | solubility water: 100 mg/mL, clear, colorless | solubility water: soluble |
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Danger
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral
target_organs
Thyroid
Storage Class
5.1A - Strongly oxidizing hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
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