8.51027
Biotin-ONp
Novabiochem®
Synonym(s):
Biotin-ONp, Biotin p-nitrophenyl ester,5-(2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid p-nitrophenyl ester
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Check Cart for Availability | $270.00 |
About This Item
Empirical Formula (Hill Notation):
C16H19N3O5S
CAS Number:
Molecular Weight:
365.40
UNSPSC Code:
12352108
NACRES:
NA.22
MDL number:
Assay:
≥97.0% (HPLC), ≥98% (TLC)
Form:
powder
Quality Segment
product line
Novabiochem®
assay
≥97.0% (HPLC), ≥98% (TLC)
form
powder
reaction suitability
reaction type: Biotinylations
manufacturer/tradename
Novabiochem®
mp
163-165 °C
application(s)
peptide synthesis
storage temp.
15-25°C
SMILES string
S1[C@H]([C@H]3NC(=O)N[C@H]3C1)CCCCC(=O)Oc2ccc(cc2)[N+](=O)[O-]
InChI
1S/C16H19N3O5S/c20-14(24-11-7-5-10(6-8-11)19(22)23)4-2-1-3-13-15-12(9-25-13)17-16(21)18-15/h5-8,12-13,15H,1-4,9H2,(H2,17,18,21)/t12-,13-,15-/m0/s1
InChI key
YUDNXDTXQPYKCA-YDHLFZDLSA-N
General description
Pre-activated reagent for the introduction of biotin by solid phase synthesis. More soluble and more reactive than 851023 [1]. This reagents has recently been found to be effective in SPOT synthesis of biotinylated peptides [2].
Associated Protocols and Technical Articles
Biotinylation Reagents for Peptide Synthesis
Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)
Literature references
[1] B. Baumeister, et al. Int. J. Pept. Res. Ther., 11, 139.
[2] D. Winkler & P. McGeer (2008) Proteomics, 8, 961.
Associated Protocols and Technical Articles
Biotinylation Reagents for Peptide Synthesis
Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)
Literature references
[1] B. Baumeister, et al. Int. J. Pept. Res. Ther., 11, 139.
[2] D. Winkler & P. McGeer (2008) Proteomics, 8, 961.
Application
- Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation: This study discusses the synthesis and applications of cell-permeant peptides involving biotin-ONP for enhanced cellular processes (Almansour, 2017).
- Structure-function analysis of tight junction-directed permeation enhancer PIP250: Provides insights into the utility of biotin-ONP in analyzing the structure and function of peptides used to enhance cellular permeation (Taverner et al., 2023).
Analysis Note
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in dioxan): +34.5 - +39.5 °
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in dioxan): +34.5 - +39.5 °
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
To see the solvent systems used for TLC of Novabiochem® products please click here.
Other Notes
Replaces: 01-63-0116
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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