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8.51029

N-Biotinyl-NH-(PEG)2-COOH . DIPEA (20 atoms)

Novabiochem®

Synonym(s):

N-Biotinyl-NH-(PEG)₂-COOH . DIPEA (20 atoms), O-(N-Biotinyl-3-aminopropyl)-O′-(N-glutaryl-3-aminopropyl)-diethyleneglycol · DIPEA

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Size/SKUAvailabilityPrice
500 mg

Estimated to ship TODAYfromSAINT LOUIS

$474.00
1 g

Estimated to ship onSeptember 16, 2026fromSAINT LOUIS

$801.00

About This Item

Empirical Formula (Hill Notation):
C25H44N4O8S · xC8H19N
CAS Number:
Molecular Weight:
560.70
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22

$474.00


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Quality Segment

product line

Novabiochem®

assay

≥95.0% (HPLC), ≥98% (TLC)

form

powder

reaction suitability

reaction type: Biotinylations

manufacturer/tradename

Novabiochem®

mp

131-136 °C

application(s)

peptide synthesis

storage temp.

2-8°C

SMILES string

S1[C@H]([C@H]2NC(=O)N[C@H]2C1)CCCCC(=O)NCCOCCOCCOC(=O)O.N(C(C)C)(C(C)C)CC

InChI

1S/C17H29N3O7S.C8H19N/c21-14(18-5-6-25-7-8-26-9-10-27-17(23)24)4-2-1-3-13-15-12(11-28-13)19-16(22)20-15;1-6-9(7(2)3)8(4)5/h12-13,15H,1-11H2,(H,18,21)(H,23,24)(H2,19,20,22);7-8H,6H2,1-5H3/t12-,13-,15-;/m0./s1

InChI key

YOALVTBRBBZXGM-HZPCBCDKSA-N

General description

The use of this novel biotin derivative incorporates a hydrophilic 20 atom PEG spacer between the peptide and biotin. This not only greatly improves the solubility of the resultant peptide, but reduces steric hindrance between the peptide and biotin, leading to better avidin binding and higher biological activity. The biotin-PEG derivative can be easily incorporated using any standard coupling method as the final step in SPPS, immediately prior to cleavage of the peptide from the resin.

Associated Protocols and Technical Articles

Biotinylation Reagents for Peptide Synthesis

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (50 mg in 1 ml NMP): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 01-63-0133

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item
852340852113852102
description

Novabiochem®

description

Novabiochem®

description

Novabiochem®

description

Novabiochem®

assay

≥95.0% (HPLC), ≥98% (TLC)

assay

≥98% (TLC)

assay

≥95.0% (HPLC), ≥98% (TLC)

assay

≥95.0% (HPLC), ≥97% (TLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

reaction suitability

reaction type: Biotinylations

reaction suitability

reaction type: Biotinylations

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

storage temp.

2-8°C

storage temp.

15-25°C

storage temp.

2-8°C

storage temp.

2-8°C

mp

131-136 °C

mp

-

mp

-

mp

-

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

  1. The molecular weight say 560, but I believe you are missing the DIPEA. What is the true MW of this compound?

    1 answer
    1. Thank you for calling this to our attention. The molecular weight of this product is 698.95 g/mol. This value will be corrected shortly.
      Please see the link below to review which offers the correct molecular weight:
      https://www.emdmillipore.com/product/N-Biotinyl-NH-PEG2-COOH-.-DIPEA-20-atoms,MDA_CHEM-851029

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