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8.51087

PyClock

6-Chloro-benzotriazole-1-yloxy-tris-pyrrolidinophosphonium hexafluorophosphate Novabiochem®

Synonym(s):

PyClock, 6-Chloro-benzotriazole-1-yloxy-tris-pyrrolidinophosphonium hexafluorophosphate

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Size/SKUAvailabilityPrice
25 g
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$198.00
100 g
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$591.00

About This Item

Empirical Formula (Hill Notation):
C18H27ClF6N6OP2
CAS Number:
Molecular Weight:
554.84
UNSPSC Code:
12352107
NACRES:
NA.22
MDL number:
Assay:
≥98.0% (HPLC)
Form:
powder

$198.00


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Quality Segment

product line

Novabiochem®

assay

≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Coupling Reactions

manufacturer/tradename

Novabiochem®

mp

165-175 °C

application(s)

peptide synthesis

storage temp.

2-8°C

SMILES string

F[P-](F)(F)(F)(F)F.[P+](N5CCCC5)(N4CCCC4)(N3CCCC3)O[n]1nnc2c1cc(cc2)Cl

InChI

1S/C18H27ClN6OP.F6P/c19-16-7-8-17-18(15-16)25(21-20-17)26-27(22-9-1-2-10-22,23-11-3-4-12-23)24-13-5-6-14-24;1-7(2,3,4,5)6/h7-8,15H,1-6,9-14H2;/q+1;-1

InChI key

QJZCQEPNBRAYQL-UHFFFAOYSA-N

General description

PyClocK is the 6-chloro analog of PyBOP. Reaction of protected amino acids with PyClocK in the presence of base generates the corresponding 6-chloro-1-benzotriazolyl (Cl-OBt) ester. These active esters are considerably more reactive than those produced when using PyBOP or HBTU, owing to 6-chloro-1-hydroxybenzotriazole (Cl-HOBt) being more acidic than HOBt. PyClocK is an excellent coupling reagent for situations where carboxyl activation may be sluggish, such as cyclizations and fragment condensations, as unlike imminium-based reagents such as HBTU and HATU excess PyClocK cannot cause end-capping of peptide chains.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): conforms
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (5% in NMP (1-Methyl-2-pyrrolidone)): clear

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item
851221851095851009
description

6-Chloro-benzotriazole-1-yloxy-tris-pyrrolidinophosphonium hexafluorophosphate Novabiochem®

description

Novabiochem®

description

Novabiochem®

description

Novabiochem®

assay

≥98.0% (HPLC)

assay

-

assay

≥99.0% (HPLC)

assay

≥99.0% (HPLC)

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

400

form

powder

form

powder

form

powder

form

powder

mp

165-175 °C

mp

-

mp

-

mp

140-155 °C

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

-10 to -25°C

storage temp.

2-8°C


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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