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Pentafluoropropionic anhydride

Name: Pentafluoropropionic anhydride
Brand: SIAL
Price: 140 USD
Availability: InStock

derivatization grade (GC derivatization), LiChropur^™, 99%

Synonym(s):

PFPA, Perfluoropropionic anhydride

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Size/SKU	Availability	Price
5 mL	Estimated to ship onNovember 03, 2026fromMILWAUKEE	$140.00
10 x 1 mL	Estimated to ship onJanuary 19, 2027fromMILWAUKEE	$249.00
25 mL	Estimated to ship onFebruary 03, 2027fromMILWAUKEE	$335.00

About This Item

Linear Formula:

(CF₃CF₂CO)₂O

CAS Number:

356-42-3

Molecular Weight:

310.05

UNSPSC Code:

23151817

NACRES:

NA.22

PubChem Substance ID:

329755875

EC Number:

206-604-2

Beilstein/REAXYS Number:

1806446

MDL number:

MFCD00000429

Assay:

99%

Form:

liquid

$140.00

Estimated to ship onNovember 03, 2026Details

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Properties

grade

derivatization grade (GC derivatization)

Quality Segment

100

assay

99%

form

liquid

quality

LiChropur^™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

technique(s)

HPLC: suitable, LC/MS: suitable, gas chromatography (GC): suitable, ion chromatography: suitable

bp

69-70 °C/735 mmHg (lit.)

density

1.571 g/mL at 25 °C (lit.)

SMILES string

FC(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)F

InChI

1S/C6F10O3/c7-3(8,5(11,12)13)1(17)19-2(18)4(9,10)6(14,15)16

InChI key

XETRHNFRKCNWAJ-UHFFFAOYSA-N

Description

Application

Derivatization reagent used in a GC-MS analysis of stereoisomer content of synthetic peptides. Also used in a GC-MS detection method for synephrine in dietary supplements.

Pentafluoropropionic anhydride (PFPA) was used as derivatization reagent for urine samples to determine the presence of codeine, morphine, 6-monoacetylmorphine, ethylmorphine, and dihydrocodeine using GC-MS in selected ion monitoring (SIM) mode. It was also used to derivatize the dry pericardial fluid sample extracts for quantification of cocaine, benzoylecgonine, and cocaethylene in pericardial fluid using GC-MS.

Learn more in the Product Information

For the preparation of volatile pentafluoropropionyl derivatives of a wide range of compounds, for example, amines and alcohols, for EC/GC.

Packaging

Clear borosilicate glass, high hydrolytic resistance (Type I)

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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This Item	252387	77292	91719
Supelco 394904 Pentafluoropropionic anhydride	Sigma-Aldrich 252387 Pentafluoropropionic anhydride	Sigma-Aldrich 77292 Pentafluoropropionic anhydride	Supelco 91719 Trifluoroacetic anhydride
description derivatization grade (GC derivatization), LiChropur^™, 99%	description 99%	description purum, ≥97.0% (GC)	description derivatization grade (GC derivatization), LiChropur^™, ≥99.0% (GC)
assay 99%	assay 99%	assay ≥97.0% (GC)	assay ≥99.0% (GC)
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
reaction suitability reagent type: derivatization reagent reaction type: Acylations	reaction suitability -	reaction suitability -	reaction suitability reagent type: derivatization reagent reaction type: Acylations, reagent type: derivatization reagent reaction type: Esterifications
density 1.571 g/mL at 25 °C (lit.)	density 1.571 g/mL at 25 °C (lit.)	density 1.571 g/mL at 25 °C (lit.)	density 1.511 g/mL at 20 °C (lit.)
bp 69-70 °C/735 mmHg (lit.)	bp 69-70 °C/735 mmHg (lit.)	bp 69-70 °C/735 mmHg (lit.)	bp 39.5-40 °C (lit.)
form liquid	form liquid	form liquid	form liquid

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Pictograms

GHS05

Signal Word

Danger

Hazard Codes

H314

Precautionary Statements

P280 - P305 + P351 + P338 - P310

Hazard Classifications

Skin Corr. 1B

supp_hazards

EUH014

Storage Class

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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