Key Documents

Dexamethasone

Name: Dexamethasone
Brand: SIAL
Price: 112 USD
Availability: InStock

VETRANAL^®, analytical standard

Synonym(s):

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

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Size/SKU	Availability	Price
250 mg	Available to ship TODAYfromMILWAUKEE	$112.00

About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₉FO₅

CAS Number:

50-02-2

Molecular Weight:

392.46

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329757092

EC Number:

200-003-9

Beilstein/REAXYS Number:

2066651

MDL number:

MFCD00064136

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Properties

grade

analytical standard

Quality Segment

100

product line

VETRANAL^®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, chromatography: suitable, gas chromatography (GC): suitable

mp

262-264 °C (lit.)

application(s)

clinical

format

neat

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... NR3C1(2908)

Description

General description

Dexamethasone is a synthetic glucocorticoid and cortisol analogue. It is used in the suppression of adrenocorticotropic hormone (ACTH) and cortisol production in normal subjects.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Dexamethasone may be used as a reference standard in the determination of dexamethasone in biological samples using high-performance liquid chromatography (HPLC).

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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1 of 1

This Item	PHR1526	31375	D8893
Supelco 46165 Dexamethasone	Supelco PHR1526 Dexamethasone	Sigma-Aldrich 31375 Dexamethasone	Sigma-Aldrich D8893 Dexamethasone
description VETRANAL^®, analytical standard	description Pharmaceutical Secondary Standard; Certified Reference Material	description tested according to Ph. Eur.	description powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)
grade analytical standard	grade certified reference material, pharmaceutical secondary standard	grade -	grade -
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) gas chromatography (GC): suitable, HPLC: suitable	technique(s) -	technique(s) cell culture \| mammalian: suitable
application(s) clinical	application(s) pharmaceutical (small molecule)	application(s) research use (small molecule)	application(s) -
format neat	format neat	format -	format -
Gene Information human ... NR3C1(2908)	Gene Information human ... NR3C1(2908)	Gene Information human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908) mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926) rat ... Ar(24208), Nr3c1(24413), Tnf(24835)	Gene Information human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908) mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926) rat ... Ar(24208), Nr3c1(24413), Tnf(24835)
storage temp. 2-8°C	storage temp. 2-30°C	storage temp. -	storage temp. 2-8°C

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Pictograms

GHS08

Signal Word

Danger

Hazard Codes

H360FD

Precautionary Statements

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

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