This is a pharmaceutical analytical standard with a high potency and can also be used for cell culture, in vitro, and in vivo applications. It is soluble in DMSO and ethanol at approximately 50 mg/mL.
46542
α-Estradiol
VETRANAL®, analytical standard
Synonym(s):
1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Available to ship TODAY | $398.00 |
About This Item
Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
Molecular Weight:
272.38
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-354-8
MDL number:
$398.00
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grade
analytical standard
Quality Segment
product line
VETRANAL®
optical activity
[α]/D 52.0 to 56.0°, c = 1 in ethanol
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤2.0% water
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
InChI key
VOXZDWNPVJITMN-SFFUCWETSA-N
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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This Item | |||
|---|---|---|---|
| description VETRANAL®, analytical standard | description powder, ≥98% (TLC) | description Pharmaceutical Secondary Standard; Certified Reference Material | description European Pharmacopoeia (EP) Reference Standard |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - | technique(s) - |
| application(s) pharmaceutical (small molecule) | application(s) - | application(s) pharmaceutical | application(s) pharmaceutical (small molecule) |
| format neat | format - | format - | format neat |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level - |
| grade analytical standard | grade - | grade certified reference material, pharmaceutical secondary standard | grade pharmaceutical primary standard |
| shelf life limited shelf life, expiry date on the label | shelf life - | shelf life - | shelf life - |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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