The pKa values are not determined for this product. Based on literature data for α-ketoglutaric acid (CAS 328-50-7): pKa1 ≈ 2.5; pKa2 ≈ 4.3. In addition, literature references a pKa ≈ 2.47 at 25°C for one dissociation step. Slight variation may occur with varying experimental conditions. This information has not been validated.
75890
α-Ketoglutaric acid
99.0-101.0% (T)
Synonym(s):
alpha-Ketoglutarate, alpha-Ketoglutaric acid, 2-Oxoglutaric acid, 2-Oxopentanedioic acid
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| Size/SKU | Availability | Price |
|---|---|---|
25 g | Estimated to ship onSeptember 08, 2026fromMILWAUKEE | $48.30 |
100 g | Estimated to ship onSeptember 08, 2026fromMILWAUKEE | $115.00 |
500 g | Estimated to ship onSeptember 08, 2026fromMILWAUKEE | $284.00 |
About This Item
Linear Formula:
HOOCCH2CH2COCOOH
CAS Number:
Molecular Weight:
146.10
UNSPSC Code:
12352115
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-330-3
Beilstein/REAXYS Number:
1705689
MDL number:
Assay:
99.0-101.0% (T)
Form:
crystals
Quality Segment
assay
99.0-101.0% (T)
form
crystals
mp
114-118 °C
solubility
H2O: 1 g/10 mL, clear to slightly hazy, colorless to almost colorless
storage temp.
2-8°C
SMILES string
OC(=O)CCC(=O)C(O)=O
InChI
1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChI key
KPGXRSRHYNQIFN-UHFFFAOYSA-N
General description
α-Ketoglutaric acid is a 2-oxocarboxylic acid (2-OCA) that is formed as a metabolite in the Kreb′s cycle.
Application
α-ketoglutaric acid along with L-arginine can undergo reduction with sodium cyanoborohydride to form the diastereomers, nopaline and isonopaline.
Other Notes
Reagent for the analysis of tryptophan; Substrate for glutamate dehydrogenase
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This Item | |||
|---|---|---|---|
| description 99.0-101.0% (T) | description analytical standard | description ≥98.5% (NaOH, titration) | description ≥98% (enzymatic) |
| assay 99.0-101.0% (T) | assay 99.0-101.0% (T) | assay ≥98.5% (NaOH, titration) | assay ≥98% (enzymatic) |
| Quality Level 300 | Quality Level - | Quality Level 200 | Quality Level 300 |
| solubility H2O: 1 g/10 mL, clear to slightly hazy, colorless to almost colorless | solubility - | solubility water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow | solubility water: 100 mg/mL, clear, colorless to faintly yellow |
| mp 114-118 °C | mp - | mp - | mp - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| form crystals | form - | form powder | form powder |
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Cual sería los pk del ácido cetoglutarico
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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