Key Documents

View All Documentation

Heptafluorobutyric anhydride

Name: Heptafluorobutyric anhydride
Brand: SIAL
Price: 276 USD
Availability: InStock

derivatization grade (GC derivatization), LiChropur^™, ≥99.0%

Synonym(s):

HFAA, HFBA, Perfluorobutyric anhydride

Select a Size

Change View

Size/SKU	Availability	Price
10 mL	Estimated to ship onJanuary 05, 2027fromMILWAUKEE	$276.00
10 x 1 mL	Available to ship TODAYfromMILWAUKEE	$332.00
50 mL	Estimated to ship onNovember 04, 2026fromMILWAUKEE	$1,470.00

About This Item

Linear Formula:

(CF₃CF₂CF₂CO)₂O

CAS Number:

336-59-4

Molecular Weight:

410.06

UNSPSC Code:

41115716

NACRES:

NA.22

PubChem Substance ID:

329767572

EC Number:

206-410-8

Beilstein/REAXYS Number:

856036

MDL number:

MFCD00000432

eCl@ss:

27150601

Assay:

≥99.0% (GC), ≥99.0%

Form:

liquid

$276.00

Estimated to ship onJanuary 05, 2027Details

Request a Custom Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

grade

derivatization grade (GC derivatization)

Quality Segment

100

assay

≥99.0% (GC), ≥99.0%

form

liquid

quality

LiChropur^™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

technique(s)

HPLC: suitable, LC/MS: suitable, gas chromatography (GC): suitable, ion chromatography: suitable

refractive index

n20/D 1.287 (lit.)

bp

108-110 °C (lit.)

mp

−43 °C (lit.)

density

1.674 g/mL at 20 °C

SMILES string

FC(F)(F)C(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C8F14O3/c9-3(10,5(13,14)7(17,18)19)1(23)25-2(24)4(11,12)6(15,16)8(20,21)22

InChI key

UFFSXJKVKBQEHC-UHFFFAOYSA-N

Description

General description

Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.

Application

Learn more in the Product Information

Packaging

Clear borosilicate glass, high hydrolytic resistance (Type I)

Analysis Note

Suitable for derivatization of aldosterone, digoxin, digitoxin and metabolites, estradiol, postaglandins F_1α and F_2α,3-oxo-Δ⁴-steroids, steroids and testosterone.

Other Notes

Reagent for 3-enol heptafluorobutyrate, heptafluorobutyrate, heptafluorobutyryl, 17-heptafluorobutyryl and 17-heptafluorobutyrate.

HFAA acylates amines, amino acids and other compounds. HFBA derivatives are highly volatile: used in GC separation

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	H1006	394912	91719
Supelco 77253 Heptafluorobutyric anhydride	Sigma-Aldrich H1006 Heptafluorobutyric anhydride	Supelco 394912 Heptafluorobutyric anhydride	Supelco 91719 Trifluoroacetic anhydride
description derivatization grade (GC derivatization), LiChropur^™, ≥99.0%	description ≥98%	description derivatization grade (GC derivatization), LiChropur^™, ≥99.0%	description derivatization grade (GC derivatization), LiChropur^™, ≥99.0% (GC)
assay ≥99.0%, ≥99.0% (GC)	assay ≥98%	assay ≥99.0%	assay ≥99.0% (GC)
reaction suitability reagent type: derivatization reagent reaction type: Acylations	reaction suitability -	reaction suitability reagent type: derivatization reagent reaction type: Acylations	reaction suitability reagent type: derivatization reagent reaction type: Acylations, reagent type: derivatization reagent reaction type: Esterifications
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
bp 108-110 °C (lit.)	bp 108-110 °C (lit.)	bp 108-110 °C (lit.)	bp 39.5-40 °C (lit.)
density 1.674 g/mL at 20 °C	density 1.674 g/mL at 20 °C (lit.)	density 1.674 g/mL at 20 °C (lit.)	density 1.511 g/mL at 20 °C (lit.)
refractive index n20/D 1.287 (lit.)	refractive index n20/D 1.287 (lit.)	refractive index n20/D 1.287 (lit.)	refractive index n20/D 1.3 (lit.)

Still not finding the right product?

Explore all of our products under Heptafluorobutyric anhydride

Pictograms

GHS05

Signal Word

Danger

Hazard Codes

H314

Precautionary Statements

P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.