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G6529

L-Glutathione reduced

≥98.0%, BioXtra

Synonym(s):

γ-L-Glutamyl-L-cysteinyl-glycine, GSH

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Size/SKUAvailabilityPrice
1 g
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$70.40
5 g
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$131.00
25 g
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$411.00

About This Item

Linear Formula:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
CAS Number:
Molecular Weight:
307.32
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-725-4
MDL number:
Beilstein/REAXYS Number:
1729812

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Product Name

L-Glutathione reduced, BioXtra, ≥98.0%

product line

BioXtra

Quality Segment

assay

≥98.0%

form

powder

impurities

≤0.02% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.1%

color

white

mp

192-195 °C (dec.) (lit.)

solubility

H2O: 0.1 M, clear, colorless

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.02%, Cu: ≤0.0005%, Fe: ≤0.001%, K: ≤0.005%, Mg: ≤0.001%, NH4+: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%

storage temp.

2-8°C

SMILES string

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChI key

RWSXRVCMGQZWBV-WDSKDSINSA-N

Application

May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Biochem/physiol Actions

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

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This Item
G6013G4251PHR1359
description

BioXtra, ≥98.0%

description

suitable for cell culture, BioReagent, ≥98.0%, powder

description

≥98.0%

description

Pharmaceutical Secondary Standard; Certified Reference Material

form

powder

form

powder

form

powder

form

-

assay

≥98.0%

assay

≥98.0%

assay

≥98.0%

assay

-

product line

BioXtra

product line

BioReagent

product line

-

product line

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

cation traces

Fe: ≤0.001%, Zn: ≤0.0005%, Mg: ≤0.001%, Pb: ≤0.001%, Cu: ≤0.0005%, K: ≤0.005%, Na: ≤0.005%, Al: ≤0.0005%, NH4+: ≤0.05%, Ca: ≤0.02%

cation traces

-

cation traces

-

cation traces

-

impurities

≤0.02% Phosphorus (P), ≤0.1% Insoluble matter

impurities

-

impurities

-

impurities

-


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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the best way to make and store solutions of Product G6529, L-Glutathione reduced?

    1 answer
    1. Reduced glutathione is soluble in water. However, aqueous solutions readily oxidize in air to oxidized glutathione, GSSG.  Therefore, it is probably best to make fresh solutions for use. Half-lives of reduced glutathione in solution at various pHs and temperatures have been reported. The half-life of reduced glutathione is increased in the presence of a chelating agent. For supporting references, please consult the product information sheet (under Documents, above).

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

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