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01897

Adenosine 5′-diphosphate disodium salt

≥90%

Synonym(s):

ADPdisodium salt, Disodium 5′-ADP, Disodium adenosine 5′-diphosphate, 5′-ADP-Na2

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250 mg
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$79.80
1 g
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$175.00

About This Item

Empirical Formula (Hill Notation):
C10H13N5Na2O10P2
CAS Number:
16178-48-6
Molecular Weight:
471.16
PubChem Substance ID:
329747370
eCl@ss:
32160414
UNSPSC Code:
41106305
NACRES:
NA.51
EC Number:
240-314-7
MDL number:
MFCD00066635
Beilstein/REAXYS Number:
7563620
Assay:
≥90%
Form:
powder or crystals
Storage temp.:
−20°C

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Quality Level

100

assay

≥90%

form

powder or crystals

optical activity

[α]20/D −29.6±1°, c = 0.5% in 0.5 M Na2HPO4

impurities

≤10% water

storage temp.

−20°C

InChI

1S/C10H15N5O10P2.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

InChI key

ORKSTPSQHZNDSC-IDIVVRGQSA-L

Application

Adenosine 5′-diphosphate disodium salt has been used as a purinergic G protein-coupled receptor P2Y12 agonistin platelet activation tests in blood samples.[1][2][3]

Biochem/physiol Actions

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by ATP synthases. ADP affects platelet activation through its interaction with purinergic receptors P2Y1 and P2Y12.[4] Upon its conversion to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.[5]

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This Item
0193001905A26209
Adenosine 5′-diphosphate disodium salt ≥90%

Sigma-Aldrich

01897

Adenosine 5′-diphosphate disodium salt

Adenosine 5′-monophosphate disodium salt ≥99.0% (HPLC)

Sigma-Aldrich

01930

Adenosine 5′-monophosphate disodium salt

Adenosine 5′-diphosphate ≥95% (HPLC)

Sigma-Aldrich

01905

Adenosine 5′-diphosphate

Adenosine 5′-triphosphate disodium salt hydrate 99%

Sigma-Aldrich

A26209

Adenosine 5′-triphosphate disodium salt hydrate

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

form

powder or crystals

form

powder

form

powder

form

-

assay

≥90%

assay

≥99.0% (HPLC)

assay

≥95% (HPLC)

assay

99%

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

2-8°C

impurities

≤10% water

impurities

≤26% water

impurities

≤15.0% water (KFT)

impurities

-

optical activity

[α]20/D −29.6±1°, c = 0.5% in 0.5 M Na2HPO4

optical activity

[α]20/D −43±2°, c = 1% in 0.5 M Na2HPO4 (dry matter)

optical activity

-

optical activity

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP1903
BCCL5815
BCCJ1727
BCCG6203
BCCD2530

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Sven Van Poucke et al.
PloS one, 13(6), e0193657-e0193657 (2018-06-22)
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal peroperative chemotherapy (HIPEC), indicated for patients with peritoneal metastases from digestive or gynecological malignancies alike, demonstrates a considerable impact on hemostatic metabolism, both on platelet and on coagulation level. The potential hemostatic interference in
Cécile H Kicken et al.
PloS one, 12(2), e0172265-e0172265 (2017-02-17)
Previous studies have shown that flow cytometry is a reliable test to quantify platelet function in stored platelet concentrates (PC). It is thought that flow cytometry is laborious and hence expensive. We have optimized the flow cytometry-based quantification of agonist
Dana Huskens et al.
PloS one, 13(2), e0192079-e0192079 (2018-02-02)
Platelet function testing with flow cytometry has additional value to existing platelet function testing for diagnosing bleeding disorders, monitoring anti-platelet therapy, transfusion medicine and prediction of thrombosis. The major challenge is to use this technique as a diagnostic test. The
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Global Trade Item Number

SKUGTIN
199346-10G04061836825669
199346-50G04061836825676
01897-1G04061838611376
01897-250MG04061838611383

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