22620
Quinine
suitable for fluorescence, anhydrous, ≥98.0% (dried material, NT)
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Synonym(s):
6′-Methoxycinchonidine
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 g | Check Cart for Availability | $98.20 |
25 g | Check Cart for Availability | $386.00 |
100 g | Check Cart for Availability | $1,020.00 |
About This Item
$98.20
Quality Segment
assay
≥98.0% (dried material, NT)
form
powder
optical activity
[α]20/D −126±5°, c = 1% in chloroform
impurities
≤5% dihydroquinine (HPLC)
loss
≤1% loss on drying, 110 °C
mp
173-175 °C (lit.)
solubility
H2O: soluble
fluorescence
λex 347 nm; λem 448 nm in 0.5 M sulfuric acid
suitability
suitable for fluorescence
SMILES string
COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
InChI
1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1
InChI key
LOUPRKONTZGTKE-WZBLMQSHSA-N
Gene Information
human ... ABCB1(5243), CYP2C9(1559), CYP2D6(1565)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)
General description
Application
- To study its in vitro antimalarial activity in combination with omeprazole.
- To analyze its effect on viscosity and friction of saliva.
- As a test agent to study its impact on the accumulation of the fluorescent P-glycoprotein (Pgp) substrates in P-glycoprotein overexpressing breast cancer cells.
- To study its influence on the pyramidal cell intrinsic properties, extracellular potassium transients, and epileptiform activity in vitro.
- As a reference compound to identify alkaloids by phytochemical screening of Deianira erubescens, Strychnos pseudoquina and Remijia ferruginea plants.
Biochem/physiol Actions
1 of 1
This Item | |||
|---|---|---|---|
| description suitable for fluorescence, anhydrous, ≥98.0% (dried material, NT) | description certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | description phyproof® Reference Substance | description 90% |
| assay ≥98.0% (dried material, NT) | assay - | assay ≥90.0% (HPLC) | assay 90% |
| form powder | form - | form - | form - |
| Quality Level 100 | Quality Level 300 | Quality Level - | Quality Level 200 |
| mp 173-175 °C (lit.) | mp 173-175 °C (lit.) | mp 173-175 °C (lit.) | mp 173-175 °C (lit.) |
| optical activity [α]20/D −126±5°, c = 1% in chloroform | optical activity - | optical activity - | optical activity [α]25/D −165°, c = 2 in ethanol |
| fluorescence λex 347 nm; λem 448 nm in 0.5 M sulfuric acid | fluorescence - | fluorescence - | fluorescence - |
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
Storage Class
11 - Combustible Solids
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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