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69591

4-Methylumbelliferyl α-D-glucopyranoside

≥98% (TLC)

Synonym(s):

4-Methylumbelliferyl α-D-glucoside

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25 mg

Available to ship TODAYfromMILWAUKEE

$101.00
100 mg

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$228.00
500 mg

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$940.00
$658.00

About This Item

Empirical Formula (Hill Notation):
C16H18O8
CAS Number:
17833-43-1
Molecular Weight:
338.31
UNSPSC Code:
12352204
NACRES:
NA.25
PubChem Substance ID:
57652200
EC Number:
241-794-0
Beilstein/REAXYS Number:
1690776
MDL number:
MFCD00067661

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Quality Level

200

description

α-glucosidase substrate

assay

≥98% (TLC)

form

powder

solubility

DMSO: 50 mg/mL, clear, colorless to faintly yellow

fluorescence

λex 316 nm; λem 375 nm (Reaction product), λex 317 nm; λem 374 nm (pH9.0), λex 360 nm; λem 449 nm, λex 365 nm; λem 445 nm in 0.1 M Tris pH 8.0 (α-glucosidase)

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/m1/s1

InChI key

YUDPTGPSBJVHCN-JZYAIQKZSA-N

General description

4-Methylumbelliferyl α-D-glucopyranoside is the fluorogenic substrate of alpha-glucosidase enzyme.[1] 4-Methylumbelliferyl α-D-glucopyranoside, also known as 4MU- α-glc, upon reaction leads to the product 4MU, which emits at the peak of 440nm in the fluorescence spectra.[2]

Application

4-Methylumbelliferyl α-D-glucopyranoside is used as a flurogenic substrate for the identification, characterization and kinetic analysis of α-D-glucosidase(s).4-Methylumbelliferyl α-D-glucopyranoside is used for high throughput screening experiments. It is suitable for the diagnosis of Pompe′s disease in kidney and leucocytes.[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
474426M9766M2133
4-Methylumbelliferyl α-D-glucopyranoside ≥98% (TLC)

Sigma-Aldrich

69591

4-Methylumbelliferyl α-D-glucopyranoside

4-Methylumbelliferyl-α-D-glucopyranoside Substrate for fluorogenic assay of α-glucosidase. Has been used in studies of Pompe disease.

Sigma-Aldrich

474426

4-Methylumbelliferyl-α-D-glucopyranoside

4-Methylumbelliferyl α-D-glucopyranoside α-glucosidase substrate

Sigma-Aldrich

M9766

4-Methylumbelliferyl α-D-glucopyranoside

4-Methylumbelliferyl N-acetyl-β-D-glucosaminide β-N-acetylhexosaminidase substrate

Sigma-Aldrich

M2133

4-Methylumbelliferyl N-acetyl-β-D-glucosaminide

assay

≥98% (TLC)

assay

≥99% (HPLC)

assay

≥99% (TLC)

assay

≥98% (TLC)

solubility

DMSO: 50 mg/mL, clear, colorless to faintly yellow

solubility

methanol: soluble

solubility

pyridine: 50 mg/mL, clear, colorless to faintly yellow

solubility

DMF: 20 mg/mL, clear, colorless to faintly yellow

Quality Level

200

Quality Level

100

Quality Level

300

Quality Level

200

form

powder

form

solid

form

powder

form

powder

storage temp.

−20°C

storage temp.

10-30°C

storage temp.

−20°C

storage temp.

−20°C

fluorescence

λex 316 nm; λem 375 nm (Reaction product), λex 360 nm; λem 449 nm, λex 317 nm; λem 374 nm (pH9.0), λex 365 nm; λem 445 nm in 0.1 M Tris pH 8.0 (α-glucosidase)

fluorescence

-

fluorescence

-

fluorescence

-

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000557457
0000536910
0000557457
0000536910
0000519438

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D M Broadhead et al.
Clinical genetics, 13(6), 504-510 (1978-06-01)
The diagnosis of Pompe's disease by the assay of acid alpha-glucosidase in kidney and leucocytes was not previously possible because of the presence of another component which had activity at pH 4.0, but was not deficient in the disease. This
Blanca I Torres-Rodríguez et al.
Antonie van Leeuwenhoek, 101(2), 313-322 (2011-09-20)
The early steps of glycoprotein biosynthesis involve processing of the N-glycan core by endoplasmic reticulum α-glucosidases I and II which sequentially trim the outermost α1,2-linked and the two more internal α1,3-linked glucose units, respectively. We have demonstrated the presence of
Toshiro Matsui et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 25(4), 559-562 (2009-04-11)
Alpha-glucosidase (AGH) from the small intestine of rat was immobilized onto a glutaraldehyde (GA) activated NH(2)-96 well microplate to establish a convenient and rapid AGH inhibition assay system. After AGH immobilization, remaining GA groups were blocked by beta-alanine to induce
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Global Trade Item Number

SKUGTIN
69591-500MG04061833278062
69591-100MG04061833278048
69591-25MG04061833278055

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