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Monoclonal Anti-Calcitonin Gene-Related Peptide antibody produced in mouse

Name: Monoclonal Anti-Calcitonin Gene-Related Peptide antibody produced in mouse
Brand: SIGMA
Price: 739 USD
Availability: InStock

clone CD8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-CGRP

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Size/SKU	Availability	Price
100 μL	Estimated to ship TODAYfromSAINT LOUIS	$739.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00162203

Conjugate:

unconjugated

Clone:

CD8, monoclonal

Application:

ICC, IF, IHC (p)

Citations:

$739.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

CD8, monoclonal

form

buffered aqueous solution

species reactivity

guinea pig, human

technique(s)

immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:1,000 using ovenight incubation at 4 °C and sections that have been protease-digested or processed by high temperature antigen retrieval, indirect immunofluorescence: 1:500 using overnight incubation at 4 °C

isotype

IgG1

UniProt accession no.

P01258

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CALCA(796)
rat ... Calca(24241)

Description

General description

Calcitonin gene-related peptide (CGRP) is a vasodilator that belongs to the calcitonin family of peptides. It is produced by motor neurons of peripheral and central nervous system. There are two forms of CGRP, α and β, which exhibit similar functions. The effects of CGRP are mediated by G-protein coupled receptor heterodimer formed by calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein 1 (RAMP1). Several biological effects of CGRP are observed in nervous, endocrine, immune and cardiovascular systems. Multiple studies have implicated CGRP in the pathophysiology of migraine and antagonists to CGRP are being explored as treatment options
Monoclonal Anti-Calcitonin Gene-Related Peptide (CGRP) recognizes human and guinea pig CGRP. It does not cross react with rat CGRP.

Immunogen

peptide corresponding to the C-terminal of rat α−calcitonin gene-related peptite (CGRP).

Application

Anti-Calcitonin Gene-Related Peptide (CGRP) antibody is suitable for immunohistochemistry at a working antibody dilution of 1:200 to 1:1000 using formalin-fixed, paraffin-embedded sections or cryostat tissue sections. The antibody may be used for immunofluorescence at a working dilution of 1:500.

Physical form

Solution in PBS containing 1% BSA and ≤ 0.1% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	C7113	C8198	AB15360
Sigma-Aldrich C9487 Monoclonal Anti-Calcitonin Gene-Related Peptide antibody produced in mouse	Sigma-Aldrich C7113 Anti-Calcitonin Gene-Related Peptide antibody, Mouse monoclonal	Sigma-Aldrich C8198 Anti-Calcitonin Gene Related Peptide antibody produced in rabbit	Sigma-Aldrich AB15360 Anti-Calcitonin Gene Related Peptide Antibody
description clone CD8, purified immunoglobulin, buffered aqueous solution	description clone 4901, purified from hybridoma cell culture	description whole antiserum	description serum, Chemicon^®
biological source mouse	biological source mouse	biological source rabbit	biological source rabbit
Gene Information human ... CALCA(796) rat ... Calca(24241)	Gene Information human ... CALCA(796) rat ... Calca(24241)	Gene Information rat ... Calca(24241)	Gene Information human ... CALCA(796)
species reactivity guinea pig, human	species reactivity rat, human, canine	species reactivity rat	species reactivity rat
antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture	antibody form whole antiserum	antibody form serum
clone CD8, monoclonal	clone 4901, monoclonal	clone polyclonal	clone polyclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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