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H4791

BMP2, human

Name: BMP2, human
Brand: SIGMA
Price: 404 EUR

BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture

Synonyme(s) :

Bone Morphogenetic Protein 2 human, BMP-2

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À vous/Référence	Disponibilité	Prix
10 μg	Vérifier la disponibilité des articles du panier	404,00 €

A propos de cet article

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD03097877

Biological source:

human

Recombinant:

expressed in HEK 293 cells

Form:

lyophilized powder

Mol wt:

dimer 30-38 kDa (glycosylated)

Impurities:

<1 EU/μg Endotoxin level

404,00 €

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Propriétés

Nom du produit

Bone Morphogenetic Protein 2 human, BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture

biological source

human

Quality Segment

100

recombinant

expressed in HEK 293 cells

form

lyophilized powder

potency

≤60 ng/mL EC₅₀

quality

endotoxin tested

mol wt

dimer 30-38 kDa (glycosylated)

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

<1 EU/μg Endotoxin level

UniProt accession no.

P12643

storage temp.

−20°C

Gene Information

human ... BMP2(650)

Description

General description

Bone Morphogenetic Protein 2 is a member of the TGF-β superfamily of cytokines that affect bone and cartilage formation. It is important for skeletal development during embryogenesis. BMP-2 induces chondrocyte formation, osteoblast differentiation, and is involved in embryo dorsal-ventral patterning and organogenesis.

Biochem/physiol Actions

It has been reported that Bone Morphogenetic Protein 2 (BMP-2) inhibits estradiol induced proliferation of human breast cancer cells. BMP-2 signaling mediates apoptosis by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors, which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified. Both BMP type I receptors bind BMP-2 with high-affinity in the absence of BMP receptor type II.

Physical form

Lyophilized from a 0.2 μm filtered solution of 2x PBS + 6% Ethanol.

Preparation Note

This Bone Morphogenetic Protein 2 (BMP-2) is produced from a DNA sequence encoding the human BMP-2 protein, expressed in HEK 293 cells. It is a glycosylated homodimer linked by a single disulfide bond with an apparent molecular mass of 30-38 kDa.

Analysis Note

The specific activity was determined by its ability to induce alkaline phosphatase production in a dose response to BMP-2 in the ATDC-5 cell line (mouse chondrogenic cell line).

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

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Cet article	B3555	B2680	B2805
Sigma-Aldrich H4791 Bone Morphogenetic Protein 2 human	Sigma-Aldrich B3555 Bone Morphogenetic Protein 2 human	Sigma-Aldrich B2680 Bone Morphogenetic Protein 4 human	Sigma-Aldrich B2805 Bone Morphogenetic Protein 6 human
description BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture	description ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture	description >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
recombinant expressed in HEK 293 cells	recombinant expressed in E. coli	recombinant expressed in NSO cells	recombinant expressed in NSO cells
biological source human	biological source human	biological source human	biological source human
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
mol wt dimer 30-38 kDa (glycosylated)	mol wt 26 kDa	mol wt monomer calculated mol wt 13 kDa, ~22 kDa by SDS-PAGE	mol wt 30–38 kDa

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Classe de stockage

11 - Combustible Solids

wgk

WGK 3

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Not applicable

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