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HPA014067

Anti-ENTPD1 antibody produced in rabbit

Name: Anti-ENTPD1 antibody produced in rabbit
Brand: SIGMA
Price: 514 EUR

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Oferta disponible

Sinónimos:

Anti-ATPDase, Anti-CD39, Anti-NTPDase-1, Anti-SPG64

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Talla/SKU	Disponibilidad	Precio
100 μL	Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	514,00 €

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UNSPSC Code:

12352203

NACRES:

NA.43

Human Protein Atlas Number:

HPA014067

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC

Citations:

514,00 €

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Propiedades

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunoblotting: 0.04-0.4 μg/mL, immunohistochemistry: 1:50-1:200

immunogen sequence

GVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFS

UniProt accession no.

P49961

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ENTPD1(953)

Descripción

Immunogen

Ectonucleoside triphosphate diphosphohydrolase 1 recombinant protein epitope signature tag (PrEST)

Application

Anti-ENTPD1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

The gene ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1) encodes a plasma membrane-bound vascular ATP diphosphohydrolase (ATPDase) that catalyzes the hydrolysis of extracellular ATP and ADP to adenosine, which associates with adenosine receptors and negatively regulates T-cell and natural killer (NK)–cell responses, resulting in a suppressed immune system. The regulatory T cell (Treg) immunosuppressive function is mainly due to the CD39/CD73 pathway that produces adenosine. The expression of CD39 is found to be higher in cancer cells than in normal cells. It is expressed by infiltrating lymphocytes, the tumor stroma, and tumor cells in cancer tissues. It may serve as a therapeutic target for inhibiting tumor cell–mediated immunosuppression.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Other Notes

Corresponding Antigen APREST72656

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Este artículo	SAB4301663	HPA002927	HPA017676
Sigma-Aldrich HPA014067 Anti-ENTPD1 antibody produced in rabbit	Sigma-Aldrich SAB4301663 Anti-ENTPD1	Sigma-Aldrich HPA002927 Anti-ENTPD5 antibody produced in rabbit	Sigma-Aldrich HPA017676 Anti-ENTPD2 antibody produced in rabbit
description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
product line Prestige Antibodies^® Powered by Atlas Antibodies	product line -	product line Prestige Antibodies^® Powered by Atlas Antibodies	product line Prestige Antibodies^® Powered by Atlas Antibodies
UniProt accession no. P49961	UniProt accession no. P49961	UniProt accession no. O75356	UniProt accession no. Q9Y5L3

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Clase de almacenamiento

10 - Combustible liquids

¿Qué está pasando?

WGK 1

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

EPI (equipos de protección individual)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number

000020331

R05076

A81346

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