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Anti-Sirt3 antibody produced in rabbit

Name: Anti-Sirt3 antibody produced in rabbit
Brand: SIGMA
Price: 686 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-SIR2L3, Anti-Sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$686.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD07784765

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

$686.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~28 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable, western blot: 2.5-5 μg/mL using human HepG2 cells

UniProt accession no.

Q9NTG7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SIRT3(23410)

Description

General description

Sirtuin 3 (Sirt3) is an NAD-dependent deacetylase localized to the mitochondrial matrix. SIRT3 encodes a 44 kDa full length form and a N-terminal 142 amino acids truncated form. It is mapped to human chromosome 11p15.5.

Immunogen

synthetic peptide corresponding to amino acids 384-399 of human SIRT3, conjugated to KLH via an N-terminal cysteine residue.

Application

Anti-Sirt3 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Sirtuin 3 (Sirt3) is mainly a nuclear protein that transfers to the mitochondria during cellular stress. In humans, Sirt3 deacetylates and activates the mitochondrial enzyme acetyl-CoA synthetase 1 (AceCS2). Sirt3 is implicated in regulating mitochondrial function and thermogenesis in brown adipocytes. Its levels have been shown to correlate with extended life span. Increased levels of Sirt3 were associated with node positive breast cancer.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	S8447	AV32390	AV32386
Sigma-Aldrich S4072 Anti-Sirt3 antibody produced in rabbit	Sigma-Aldrich S8447 Anti-Sirt2 antibody produced in rabbit	Sigma-Aldrich AV32390 Anti-SIRT5 antibody produced in rabbit	Sigma-Aldrich AV32386 Anti-SIRT1 antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody	description affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
UniProt accession no. Q9NTG7	UniProt accession no. Q8IXJ6	UniProt accession no. Q9NXA8	UniProt accession no. Q96EB6
Gene Information human ... SIRT3(23410)	Gene Information human ... SIRT2(22933) mouse ... Sirt2(64383) rat ... Sirt2(361532)	Gene Information human ... SIRT5(23408)	Gene Information human ... SIRT1(23411)

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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