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T2928

Anti-Tyrosine Hydroxylase Antibody

Name: Anti-Tyrosine Hydroxylase Antibody
Brand: SIGMA
Price: 527 EUR

mouse monoclonal, TH-16

Sinónimos:

Anti-DYT14, Anti-DYT5b, Anti-TYH

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A ustedes/SKU	Disponibilidad	Precio
100 μL	Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	527,00 €
0.2 mL	Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	635,00 €

Acerca de este artículo

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00213051

Conjugate:

unconjugated

Clone:

TH-16, monoclonal

Application:

ARR, IHC, IP, WB

Citations:

209

527,00 €

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Propiedades

Nombre del producto

Monoclonal Anti-Tyrosine Hydroxylase antibody produced in mouse, clone TH-16, ascites fluid

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

TH-16, monoclonal

contains

15 mM sodium azide

species reactivity

rat, sheep, human, monkey, bovine, rabbit, guinea pig

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable using native or SDS-denatured TH., microarray: suitable, western blot: 1:8,000 using extracts of cultured rat adrenal pheochromocytoma (PC12) cells.

isotype

IgG1

UniProt accession no.

P07101

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TH(7054)
rat ... Th(25085)

Descripción

General description

Monoclonal Anti-Tyrosine Hydroxylase (mouse IgG1 isotype) is derived from the TH-16 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Tyrosine hydroxylase (TH) exists in four isoforms in humans. They are are TH-1 (M.W. 55,600), TH-2 (4 additional amino acids; M.W. 56,000), TH-3, (27 additional amino acids; M.W. 58,100), and TH-4 (4 plus 27 additional amino acids; 58,500). Only humans express all four isoforms; all other anthropoids express only the TH-1 and TH-2 isoforms.

Tyrosine hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15. TH is a tetramer of four identical subunits, which is characterized with a regulatory, catalytic and tetramerization domains. The enzyme utilizes tyrosine, tetrahydrobiopterin (BH₄) and O₂ as cosubstrates, and Fe²⁺ as a cofactor.

Immunogen

rat tyrosine hydroxylase (TH).

Application

Monoclonal Anti-Tyrosine Hydroxylase antibody produced in mouse has also been used in

western blotting[1]
immunofluorescence labelling
immunohistochemical staining[2]
enzyme linked immunosorbent assay (ELISA)
dot blot
immunoprecipitation
immunocytochemistry

Monoclonal Anti-tyrosine hydroxylase antibody produced in mouse has been used in immunohistochemistry and double immunofluorescence labeling.[3][4]

Biochem/physiol Actions

The antibody recognizes an epitope present in the N-terminal region (between aa 40-152) of both rodent and human tryosine hydroxylase. TH-16 detects both the intact subunits and the 59/57 kDa doublet and an array of decreasing molecular weight TH forms resulting from severe proteolysis.

Tyrosine hydroxylase (TH) catalyzes the first rate limiting step in the biosynthesis of catecholamine neurotransmitter i.e. the conversion of L-tyrosine to L-dopa. Inhibition of TH by L-phenylalanine, might play a crucial role in phenylketonuria and block the synthesis of norepinephrine. Activity of TH can be regulated by phosphorylation. Decreased expression of TH is associated with various neuropsychiatric diseases such as schizophrenia and Parkinson′s disease (PD).

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Este artículo	T1299	MAB318	AB152
Sigma-Aldrich T2928 Monoclonal Anti-Tyrosine Hydroxylase antibody produced in mouse	Sigma-Aldrich T1299 Monoclonal Anti-Tyrosine Hydroxylase antibody produced in mouse	Sigma-Aldrich MAB318 Anticuerpo anti- tirosina hidroxilasa, clon LNC1	Sigma-Aldrich AB152 Anticuerpo anti-tirosina hidroxilasa
species reactivity rat, sheep, human, monkey, bovine, rabbit, guinea pig	species reactivity human, monkey, guinea pig, rat, sheep, bovine, rabbit	species reactivity zebrafish, mouse, rat, vole, human, frog, lizard, monkey, chicken	species reactivity human, mollusk, feline, ferret, Aplysia (marine mollusc), rat, squid, Drosophila, mouse
biological source mouse	biological source mouse	biological source mouse	biological source rabbit
clone TH-16, monoclonal	clone TH-2, monoclonal	clone LNC1, monoclonal	clone polyclonal
antibody form ascites fluid	antibody form ascites fluid	antibody form ascites fluid	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate -	conjugate -
Gene Information human ... TH(7054) rat ... Th(25085)	Gene Information human ... TH(7054) rat ... Th(25085)	Gene Information human ... TH(7054) rat ... Th(25085)	Gene Information human ... TH(7054) rat ... Th(25085)

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Clase de almacenamiento

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c