Skip to Content

Legal compliance reminder: purchasers must obtain all necessary licenses and comply with applicable laws (see General Terms & Conditions of Sale). We reserve the right to request additional information.

MilliporeSigma

Key Documents

View All Documentation

Skip To

A129

Amoxapine

Promotion Available

Synonym(s):

2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
100 mg

Estimated to ship TODAYfromMILWAUKEE

$58.20
$49.47
500 mg
Check Cart for Availability
$229.00
5 g
Check Cart for Availability
$1,040.00

About This Item

Empirical Formula (Hill Notation):
C17H16ClN3O
CAS Number:
14028-44-5
Molecular Weight:
313.78
NACRES:
NA.77
PubChem Substance ID:
24278075
UNSPSC Code:
12352200
EC Number:
237-867-1
MDL number:
MFCD00069210
Form:
powder

$49.47

List Price$58.20Save 15%
Web-Only Promotion

Estimated to ship TODAYDetails

​
Request a Custom Order
​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

form

powder

Quality Segment

100

solubility

methanol: soluble

originator

Wyeth

SMILES string

Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1

InChI

1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2

InChI key

QWGDMFLQWFTERH-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

Application

Amoxapine has been used as an antidepressant drug to test its effect on locomotion and egg release in response to gain-of-functional mutations in potassium (K+) channels (unc-58) of C. elegans. It has also been used as an antipsychotic drug to test its effect on the viability of glioblastoma cells.

Biochem/physiol Actions

Amoxapine, a structural analog of clozapine, is a human ether a-go-go (hERG) channel blocker. It is also an N-methylated metabolite of loxapine. It is a tricyclic antidepressant that inhibits the uptake of norepinephrine and blocks 5- hydroxytryptamine (HT2 ) serotonergic receptors.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
1031401PHR18411031478
Amoxapine

Sigma-Aldrich

A129

Amoxapine

Amoxapine United States Pharmacopeia (USP) Reference Standard

USP

1031401

Amoxapine

Amoxapine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1841

Amoxapine

USP

USP

1031478

Amoxapine Related Compound G

description

-

description

United States Pharmacopeia (USP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

United States Pharmacopeia (USP) Reference Standard

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

-

solubility

methanol: soluble

solubility

-

solubility

-

solubility

-

originator

Wyeth

originator

-

originator

-

originator

-

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), SLC6A2(6530), SLC6A4(6532)

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), SLC6A2(6530), SLC6A4(6532)

Gene Information

-

Still not finding the right product?

Explore all of our products under Amoxapine

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    071K1160
    121K1611
    BCBB6438V
    BCBB6438

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Questions

    Reviews

    No rating value

    Active Filters