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A1388

Adenosine 5′-[γ-thio]triphosphate tetralithium salt

≥75% (HPLC), synthetic (organic), powder

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Synonym(s):

ATP-γ-S, Adenosine 5′-(3-thiotriphosphate) tetralithium salt, Ado-5′-PPP[S]

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1 mg
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$130.00
5 mg
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$326.00
25 mg
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$764.00

About This Item

Empirical Formula (Hill Notation):
C10H12Li4N5O12P3S
CAS Number:
Molecular Weight:
546.98
NACRES:
NA.51
PubChem Substance ID:
eCl@ss:
32160414
UNSPSC Code:
41106305
EC Number:
298-862-8
MDL number:
Beilstein/REAXYS Number:
6265083
Assay:
≥75% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
H2O: 25 mg/mL
Storage temp.:
−20°C

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Product Name

Adenosine 5′-[γ-thio]triphosphate tetralithium salt, ≥75% (HPLC), powder

biological source

synthetic (organic)

Quality Segment

assay

≥75% (HPLC)

form

powder

color

white to off-white

solubility

H2O: 25 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1

InChI key

DWQFDOIBOYDYKH-KWIZKVQNSA-J

Application

Adenosine 5′-[γ-thio]triphosphate tetralithium salt has been used to treat the pollen grains to determine the inhibitory effect of adenosine triphosphate (ATP) or its hydrolysis product. It has also been used to select thiophosphorylate target protein.

Biochem/physiol Actions

Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca2+-activated K+ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death.

Other Notes

Non-hydrolyzable ATP analog

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This Item
119120119123A2647
description

≥75% (HPLC), powder

description

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

description

A phosphatase-resistant ATP analogue.

description

≥93% (HPLC), powder

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

natural (organic)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

form

powder

form

solid

form

liquid

form

powder

assay

≥75% (HPLC)

assay

≥85% (HPLC)

assay

>90% (HPLC)

assay

≥93% (HPLC)

shipped in

dry ice

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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