This product is a research grade chemical and not a pharmaceutical product. While the same active enantiomer (R-(−)-apomorphine) is an approved medicine, it is not manufactured, packaged, or regulated as a clinical dosage form, so it should not be used in humans.
A4393
R-(−)-Apomorphine hydrochloride hemihydrate
calcined, ≥98% (with NaOH, titration)
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 mg | Please contact Customer Service for Availability | $83.20 | |
| 250 mg | Please contact Customer Service for Availability | $156.00 | |
| 1 g | Please contact Customer Service for Availability | $434.00 | |
| 5 g | Please contact Customer Service for Availability | $1,560.00 |
About This Item
Linear Formula:
C17H17NO2 · HCl · 1/2H2O
CAS Number:
Molecular Weight:
312.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
206-243-0
MDL number:
Assay:
≥98% (with NaOH, titration)
Form:
calcined, (Powder to Crystalline Powder)
Quality level:
Storage condition:
protect from light, under inert gas
Quality Level
assay
≥98% (with NaOH, titration)
form
calcined, (Powder to Crystalline Powder)
storage condition
protect from light, under inert gas
color
white to gray
mp
285-287 °C (lit.)
solubility
H2O: ~10 mg/mL, clear, yellow-green
SMILES string
Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68
InChI
1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1
InChI key
CXWQXGNFZLHLHQ-DPFCLETOSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
Application
R-(-)-Apomorphine hydrochloride hemihydrate has been used as a dopamine receptor agonist to study its effects of rotational behavior in rat models of Parkinson′s disease.[1]
Biochem/physiol Actions
R-(−)-Apomorphine acts as a non-selective D1 and D2 dopamine receptor agonist. It shows therapeutic effects against Parkinson′s disease and male erectile dysfunction. R-(−)-Apomorphine also shows neuroprotective, radical scavenging, and emetic effects. Apomorphine stimulates the brain chemoreceptor trigger zone. It stimulates the chemoreceptor trigger zone in the brain.
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This Item | |||
|---|---|---|---|
| assay ≥98% (with NaOH, titration) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| form calcined, (Powder to Crystalline Powder) | form solid | form solid | form solid |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: ~10 mg/mL, clear, yellow-green | solubility DMSO: ~14 mg/mL, H2O: >5 mg/mL | solubility DMSO: >20 mg/mL, H2O: ≥5 mg/mL | solubility H2O: 22 mg/mL at ~60 °C |
| storage condition protect from light, under inert gas | storage condition desiccated, under inert gas | storage condition desiccated, under inert gas | storage condition under inert gas |
| mp 285-287 °C (lit.) | mp - | mp - | mp - |
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Kristina Malinovskaja et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 83(3), 477-484 (2012-12-05)
The objective of this study was to test a drug delivery system that combines iontophoresis and cation-exchange fibers as drug matrices for the controlled transdermal delivery of antiparkinsonian drug apomorphine. Positively charged apomorphine was bound to the ion-exchange groups of
Qian Li et al.
Neuron, 76(5), 1030-1041 (2012-12-12)
Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN)
Yanpeng Yuan et al.
Theranostics, 8(17), 4679-4694 (2018-10-04)
Autologous neural stem cells (NSCs) may offer a promising source for deriving dopaminergic (DA) cells for treatment of Parkinson's disease (PD). Methods: By using Sendai virus, human peripheral blood mononuclear cells (PBMNCs) were reprogrammed to induced NSCs (iNSCs), which were
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A4393-5G | 04061832088648 |
| A4393-100MG | 04061833374399 |
| A4393-250MG | 04061833374412 |
| A4393-1G | 04061833374405 |