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A6933

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

≥97% (HPLC), powder

Synonym(s):

Ac-QKLVFF-NH2, amyloid blocker

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Pack SizeSKUAvailabilityPrice
1 mg

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$72.80
$61.88

About This Item

Empirical Formula (Hill Notation):
C42H63N9O8
CAS Number:
189064-06-0
Molecular Weight:
822.01
NACRES:
NA.32
PubChem Substance ID:
329770908
UNSPSC Code:
12352202
MDL number:
MFCD17215285
Form:
powder
Assay:
≥97% (HPLC)

$61.88

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Quality Level

200

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P05067

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(N)=O

InChI

1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1

InChI key

DDXTVYDSGCHGAN-PITCCTKHSA-N

Gene Information

human ... APP(351)

Biochem/physiol Actions

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

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A4559S4316ABN240
Acetyl-Amyloid β-Protein Fragment 15-20 Amide ≥97% (HPLC), powder

Sigma-Aldrich

A6933

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

Amyloid β-Protein Fragment 25-35 ≥97% (HPLC)

Sigma-Aldrich

A4559

Amyloid β-Protein Fragment 25-35

Amyloid Precursor Protein β, Secreted human recombinant, expressed in E. coli (N-terminal histidine tagged), solution

Sigma-Aldrich

S4316

Amyloid Precursor Protein β, Secreted human

Anti-Amyloid, β 1-40, aβ Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABN240

Anti-Amyloid, β 1-40, aβ Antibody

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

-

assay

-

form

powder

form

powder

form

solution

form

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

-

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
067H0822

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L O Tjernberg et al.
The Journal of biological chemistry, 271(15), 8545-8548 (1996-04-12)
Polymerization of amyloid beta-peptide (Abeta) into amyloid fibrils is a critical step in the pathogenesis of Alzheimer's disease. Here, we show that peptides incorporating a short Abeta fragment (KLVFF; Abeta16-20) can bind full-length Abeta and prevent its assembly into amyloid
L O Tjernberg et al.
The Journal of biological chemistry, 272(19), 12601-12605 (1997-05-09)
We have previously shown that short peptides incorporating the sequence KLVFF can bind to the approximately 40amino acid residue Alzheimer amyloid beta-peptide (Abeta) and disrupt amyloid fibril formation (Tjernberg, L. O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A. R.

Global Trade Item Number

SKUGTIN
A6933-1MG04061826671047

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