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A8843

AM580

≥98% (HPLC), RAR-α agonist, solid

Synonym(s):

4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$261.00

About This Item

Empirical Formula (Hill Notation):
C22H25NO3
CAS Number:
Molecular Weight:
351.44
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$261.00


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Product Name

AM580, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc3ccc(cc3)C(O)=O

InChI

1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

InChI key

SZWKGOZKRMMLAJ-UHFFFAOYSA-N

Gene Information

General description

AM580 is a retinobenzoic derivative and a RAR-α (retinoic acid receptor-α) agonist. It stimulates the maturation of granulocytes in NB4 promyelocytic leukemia cell line and APL (acute promyelocytic leukemia) blasts. AM580 suppresses endometrial cancer cell proliferation.

Application

Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation.

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This Item
C58651674004PHR1187
description

≥98% (HPLC)

description

≥98% (HPLC), solid

description

United States Pharmacopeia (USP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

form

solid

form

solid

form

-

form

solid

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

300

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

-10 to -25°C

Gene Information

human ... RARA(5914), RARB(5915)

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916)

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916)

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916)


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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