This product is chemically synthesized.
A9650
Angiotensin I human acetate salt hydrate
≥90% (HPLC), powder, suitable for mammalian cell culture
Synonym(s):
5-Ile-angiotensin I, 5-Isoleucine-angiotensin I, Pepsitensin, Proangiotensin, Hypertensin I
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 mg | Please contact Customer Service for Availability | PLN 173.00 | |
| 5 mg | Please contact Customer Service for Availability | PLN 668.00 | |
| 10 mg | Please contact Customer Service for Availability | PLN 1,030.00 | |
| 50 mg | Please contact Customer Service for Availability | PLN 3,650.00 PLN 3,102.50 |
About This Item
Empirical Formula (Hill Notation):
C62H89N17O14 · xC2H4O2 · yH2O
CAS Number:
Molecular Weight:
1296.48 (anhydrous free base basis)
UNSPSC Code:
12352202
eCl@ss:
42020611
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Form:
powder
Assay:
≥90% (HPLC)
Biological source:
human
Mol wt:
1296 Da by calculation (Average Mass)
biological source
human
Quality Level
assay
≥90% (HPLC)
form
powder
mol wt
1296 Da by calculation (Average Mass)
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
cell culture | mammalian: suitable
solubility
acetic acid: 25 mg/mL, clear, colorless
UniProt accession no.
storage temp.
−20°C
SMILES string
CC(O)=O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(O)=O
InChI
1S/C62H89N17O14.2C2H4O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;2*1-2(3)4/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);2*1H3,(H,3,4)/t35-,41-,42-,43-,44-,45+,46-,47-,48-,50-,51-;;/m0../s1
InChI key
CKIFOTYDIFUKEP-AUVUXLIHSA-N
Gene Information
human ... AGT(183)
General description
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH3COOH.6H2O
Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.
Research area: Cell Signaling
Research area: Cell Signaling
Application
Angiotensin I human acetate salt hydrate has been used:
- as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
- to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis
- as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry[1]
Biochem/physiol Actions
Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
Putative neurotransmitter; precursor of angiotensin II and of angiotensin fragment 1-7.
Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system[2] aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.
1 of 1
This Item | |||
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) protein expression: suitable | technique(s) cell culture | mammalian: suitable |
| biological source human | biological source synthetic | biological source human | biological source mouse |
| assay ≥90% (HPLC) | assay ≥93% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (SDS-PAGE and HPLC) |
| form powder | form powder | form powder | form lyophilized powder |
| mol wt 1296 Da by calculation (Average Mass) | mol wt - | mol wt 2098.20 | mol wt predicted mol wt ~7.6 kDa |
| storage condition (Keep container tightly closed in a dry and well-ventilated place) | storage condition (Keep container tightly closed in a dry and well-ventilated place) | storage condition (Keep container tightly closed in a dry and well-ventilated place) | storage condition - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Toward Systeme International d?Unite-traceable protein quantification: from amino acids to proteins
Burkitt W I, et al.
Analytical biochemistry, 376(2), 242-251 (2008)
R A Santos et al.
Regulatory peptides, 91(1-3), 45-62 (2000-09-01)
The renin-angiotensin system is a major physiological regulator of arterial pressure and hydro-electrolyte balance. Evidence has now been accumulated that in addition to angiotensin (Ang) II other Ang peptides [Ang III, Ang IV and Ang-(1-7)], formed in the limited proteolysis
Physiology, Renin Angiotensin System
Fountain J H. and Lappin S L.
StatPearls [Internet] (2022)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A9650-1MG | 04061833412152 |
| A9650-5MG | 04061833412176 |
| A9650-50MG | 04061833412169 |
| A9650-10MG | 04061833412145 |
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「A9650 アンジオテンシン I (ヒト) 酢酸塩 水和物」 本製品の由来はヒト組織からの抽出物になりますでしょうか。あるいは化学合成品でしょうか。 ご教示いただけるとありがたいです。
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