A9883
ADA
≥98% (titration)
Synonym(s):
N-(2-Acetamido)iminodiacetic acid, N-(Carbamoylmethyl)iminodiacetic acid
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About This Item
Linear Formula:
H2NCOCH2N(CH2CO2H)2
CAS Number:
Molecular Weight:
190.15
UNSPSC Code:
12161700
NACRES:
NA.25
PubChem Substance ID:
EC Number:
247-530-0
Beilstein/REAXYS Number:
1787181
MDL number:
Quality Level
assay
≥98% (titration)
form
powder
pH
1.5-3.0
useful pH range
6.0-7.2
pKa (25 °C)
6.6
mp
219 °C (dec.) (lit.)
solubility
1 M NaOH: 160 mg/mL, clear, colorless
application(s)
diagnostic assay manufacturing
storage temp.
room temp
SMILES string
NC(=O)CN(CC(O)=O)CC(O)=O
InChI
1S/C6H10N2O5/c7-4(9)1-8(2-5(10)11)3-6(12)13/h1-3H2,(H2,7,9)(H,10,11)(H,12,13)
InChI key
QZTKDVCDBIDYMD-UHFFFAOYSA-N
General description
ADA is a zwitterionic buffer used in biochemistry and molecular biology. It is one of the Good buffers developed in the 1960′s to provide buffers in the pH range of 6.15 - 8.35 for wide applicability to biochemical studies. The pioneering publication by Good and co-workers describes the synthesis of ADA and its physical properties. The useful range of ADA buffer in aqueous solution is 6.0 - 7.2.
Application
Biological buffer component with sodium hydroxide and sodium chloride (pH 5.67-7.57, useful pH range 6.4-7.4). Used to prepare immobilized pH gradients.
Preparation Note
This product is soluble in 1 M NaOH (160mg/mL), yielding a clear, colorless solution.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Product Information Sheet
Hydrogen ion buffers for biological research
Good NE, et al.
Biochemistry, 5( (2), 467-477 (1966)
Johannan F Brandse et al.
Journal of Crohn's & colitis, 9(11), 973-981 (2015-06-28)
High serum concentrations of infliximab [IFX] and adalimumab [ADA] may be associated with adverse effects in patients with inflammatory bowel disease [IBD]. We aimed to investigate whether high anti-tumour necrosis factor [TNF] trough levels [TLs] were associated with toxicity and
Harold Bays et al.
The Journal of clinical endocrinology and metabolism, 100(8), 3140-3148 (2015-06-02)
Despite current standard of care, many patients at high risk of cardiovascular disease (CVD) still have elevated low-density lipoprotein cholesterol (LDL-C) levels. Alirocumab is a fully human monoclonal antibody inhibitor of proprotein convertase subtilisin/kexin type 9. The objective of the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A9883-250G | 04061832546506 |
| A9883-100G | 04061832546490 |
| A9883-1KG | 04061835265183 |
| A9883-25G | 04061833412626 |