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B1401

Bradykinin Fragment 1-5

≥97% (HPLC)

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Pack SizeSKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$89.30
5 mg

Available to ship TODAYfromMILWAUKEE

$314.00

About This Item

Empirical Formula (Hill Notation):
C27H40N8O6
CAS Number:
23815-89-6
Molecular Weight:
572.66
NACRES:
NA.32
PubChem Substance ID:
24891591
UNSPSC Code:
12352200
MDL number:
MFCD00076260
Form:
powder
Assay:
≥97% (HPLC)

$89.30

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Quality Level

200

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P01042

storage temp.

−20°C

SMILES string

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O

InChI

1S/C27H40N8O6/c28-18(9-4-12-31-27(29)30)24(38)35-14-6-11-21(35)25(39)34-13-5-10-20(34)23(37)32-16-22(36)33-19(26(40)41)15-17-7-2-1-3-8-17/h1-3,7-8,18-21H,4-6,9-16,28H2,(H,32,37)(H,33,36)(H,40,41)(H4,29,30,31)

InChI key

USSUMSBPLJWFSZ-UHFFFAOYSA-N

Gene Information

human ... KNG1 (includes EG:3827)

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
B1901K1632AV45680
Bradykinin Fragment 1-5 ≥97% (HPLC)

Sigma-Aldrich

B1401

Bradykinin Fragment 1-5

Bradykinin Fragment 2-9 ≥97% (HPLC)

Sigma-Aldrich

B1901

Bradykinin Fragment 2-9

Kininogen high molecular weight, Two Chain from human plasma lyophilized powder

Sigma-Aldrich

K1632

Kininogen high molecular weight, Two Chain from human plasma

Anti-KNG1 antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

AV45680

Anti-KNG1 antibody produced in rabbit

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

-

assay

-

form

powder

form

powder

form

lyophilized powder

form

buffered aqueous solution

UniProt accession no.

P01042

UniProt accession no.

P01042

UniProt accession no.

P01042

UniProt accession no.

P01042

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... KNG1 (includes EG:3827)(3827)

Gene Information

human ... KNG1 (includes EG:3827)(3827)

Gene Information

human ... KNG1(3827), KNG1 (includes EG:3827)(3827)

Gene Information

human ... KNG1(3827)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6295
BCCG5734
BCBV6317
BCBR9832V
BCBM5382V

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Mitsuhiro Hirata et al.
British journal of pharmacology, 135(1), 29-36 (2002-01-12)
1. The involvement of bradykinin (BK) B(2) receptor in acute pancreatitis induced by pancreaticobiliary duct ligation was investigated in rats. 2. The activities of amylase and lipase in the serum, the water content of the pancreas, and vacuolization of the
Mias Pretorius et al.
Clinical pharmacology and therapeutics, 76(4), 379-387 (2004-10-08)
This study tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitors potentiate activation of the kallikrein-kinin system during cardiopulmonary bypass (CPB). The effects of CPB on concentrations of bradykinin and its metabolite bradykinin 1-5 (BK1-5) were determined in 31 patients taking
S A Doggrell
Expert opinion on investigational drugs, 10(8), 1567-1569 (2002-01-12)
When the defence response of the body to infectious bacteria fails, septic shock ensues with hypotension and death. RPPGF,(1-5)-bradykinin, was until recently considered to be an active metabolite of bradykinin. In an animal model of septicaemia (lipopolysaccharide administration to rats)
View All Related Papers

Global Trade Item Number

SKUGTIN
B1401-1MG04061833422892
B1401-5MG04061832674544

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