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B7148

Buspirone hydrochloride

≥99% (TLC), powder, 5-HT1A serotonin receptor agonist

Synonym(s):

N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

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1 g
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$122.00
5 g
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$461.00

About This Item

Empirical Formula (Hill Notation):
C21H31N5O2 · HCl
CAS Number:
33386-08-2
Molecular Weight:
421.96
NACRES:
NA.77
PubChem Substance ID:
24278079
UNSPSC Code:
12352200
EC Number:
251-489-4
MDL number:
MFCD00078569
Form:
powder
Quality level:
100

$122.00

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Product Name

Buspirone hydrochloride,

form

powder

Quality Level

100

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

Cl[H].O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4

InChI

1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

InChI key

RICLFGYGYQXUFH-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

Biochem/physiol Actions

5-HT1A serotonin receptor agonist; anxiolytic.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
PHR19171078802Y0000131
Buspirone hydrochloride

Sigma-Aldrich

B7148

Buspirone hydrochloride

Buspirone hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1917

Buspirone hydrochloride

Buspirone hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1078802

Buspirone hydrochloride

Buspirone hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0000131

Buspirone hydrochloride

form

powder

form

solid

form

-

form

-

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

originator

Bristol-Myers Squibb

originator

-

originator

-

originator

-

Gene Information

human ... HTR1A(3350)

Gene Information

human ... HTR1A(3350)

Gene Information

human ... HTR1A(3350)

Gene Information

human ... HTR1A(3350)

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK4551
BCCG0755
BCCC9648
BCBZ3793
BCBW1483

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Related Content

Product Information Sheet - B7148

Product Information Sheet

E Meller et al.
Molecular pharmacology, 37(2), 231-237 (1990-02-01)
The irreversible receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was used to determine the relationship between receptor occupancy and response at central 5-hydroxytryptamine1A (5-HT1A) serotonin receptors mediating the inhibition of serotonin synthesis in rat cortex and hippocampus. Rats were treated with vehicle or
G Tunnicliff
Pharmacology & toxicology, 69(3), 149-156 (1991-09-01)
Buspirone has been available in the United States for over four years for the treatment of anxiety. It was anticipated this drug would offer certain advantages over the established benzodiazepines. In contrast to diazepam, early studies found no evidence for
Repurposing buspirone for drug addiction treatment.
Bernard Le Foll et al.
The international journal of neuropsychopharmacology, 16(2), 251-253 (2012-11-24)
View All Related Papers

Global Trade Item Number

SKUGTIN
B7148-5G04061833441558
B7148-1G04061833441541

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