The stability of this compound in solution, specifically in DMSO, has not been evaluated. However, external sources note that Budesonide is stable in DMSO for up to 1 year at -20°C or up to 2 years at -80°C. Store in working aliquots, avoid repeated freeze/thaw cycles.
B7777
Budesonide
≥99%, anti-inflammatory, powder
Synonym(s):
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 250 mg | Please contact Customer Service for Availability | $382.00 |
About This Item
Empirical Formula (Hill Notation):
C25H34O6
CAS Number:
Molecular Weight:
430.53
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
257-139-7
MDL number:
Product Name
Budesonide, ≥99%
Quality Level
assay
≥99%
form
powder
originator
AstraZeneca
SMILES string
[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H]5OC(CCC)O[C@@]45C(=O)CO
InChI
1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
InChI key
VOVIALXJUBGFJZ-KWVAZRHASA-N
Gene Information
human ... IFNG(3458), IL5(3567), NR3C1(2908)
rat ... Nr3c1(24413)
Biochem/physiol Actions
Second generation glucocorticoid with low systemic absorption; anti-inflammatory agent; inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein.
Budesonide is a second generation glucocorticoid with low systemic absorption. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis, and inflammatory bowel disease. It inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein in primary human bronchial epithelial cells. Budesonide is currently in clinical trials for the prevention of lung cancer. It shows inhibitory effects on benzo[a]pyrene-induced carcinogenesis of the lung in mice.
Features and Benefits
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| form powder | form - | form - | form - |
| assay ≥99% | assay ≥97% | assay - | assay - |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level - |
| originator AstraZeneca | originator Roche | originator - | originator - |
| Gene Information human ... IFNG(3458), IL5(3567), NR3C1(2908) | Gene Information - | Gene Information human ... NR3C1(2908) | Gene Information - |
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signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - Skin Sens. 1 - STOT RE 1 Inhalation
target_organs
Adrenal gland
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Anne Bergeron et al.
American journal of respiratory and critical care medicine, 191(11), 1242-1249 (2015-04-04)
Systemic steroids are the standard treatment for bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) despite their poor efficacy and disabling side effects. To evaluate the effectiveness and tolerance of budesonide/formoterol as an alternative treatment for BOS
James Fingleton et al.
The Journal of allergy and clinical immunology, 136(3), 601-609 (2015-03-10)
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous disorders encompassing different phenotypes of airflow obstruction, which might differ in their response to treatment. The aim of this study was to determine distinct phenotypes comprising the syndromes of asthma and
Koremu K Meja et al.
American journal of respiratory cell and molecular biology, 39(3), 312-323 (2008-04-19)
Oxidative stress as a result of cigarette smoking is an important etiologic factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), a chronic steroid-insensitive inflammatory disease of the airways. Histone deacetylase-2 (HDAC2), a critical component of the corticosteroid anti-inflammatory
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B7777-250MG | 04061833442098 |
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I resuspended 250mg in 581µl of DMSO (soluble). How should I store this and for how long can I keep it. Thank you in advance :)
1 answer-
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