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C1103

Anti-Calcium Channel (α1 Subunit), Pan antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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0.05 mL
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$384.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02095955
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
8

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biological source

rabbit

Quality Segment

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat

technique(s)

immunohistochemistry: suitable using rat heart sections (The epitope can be masked by other subunits in some Ca2+ channels.), western blot: 1:200 using rat brain membranes

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cacna1c(12288)
rat ... Cacna1c(24239)

Immunogen

synthetic peptide corresponding to amino acids 1506-1524 of the α1S subunit of rat skeletal muscle voltage-gated calcium channel (VGCC, CP15) (Accession P22002) with additional N-terminal cysteine, conjugated to MBS-KLH.

Application

Anti-Calcium Channel (α1 Subunit), Pan antibody produced in rabbit is suitable for immunohistochemistry (using rat heart sections) and western blotting at a dilution of 1:200 using rat brain membranes.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Biochem/physiol Actions

Calcium channel, voltage-dependent, L type, α1C subunit (Cav1.2) is a protein encoded by the CACNA1C gene in humans and belongs to the family of voltage-gated calcium channels. It serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate different physiological events. CACNA1C is a subunit of L-type voltage-dependent calcium channel. It is mapped to chromosome 12p13.3 and is implicated as a susceptibility gene for schizophrenia. CACNA1C is selectively expressed in human TH2 cells and blockage of Cav1.2 channel activation in TH2 cells may represent new strategies to treat allergic diseases in human subjects. Its increased activity is implicated in the pathogenesis of dementia and Alzheimer′s disease (AD).
The epitope recognized by this antibody is masked by α2 and δ chains; therefore, the antibody binds only after subunit dissociation using Triton X-100 or other detergents.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-Calcium Channel (α1 Subunit), Pan antibody produced in rabbit affinity isolated antibody, lyophilized powder

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description

affinity isolated antibody, lyophilized powder

description

affinity isolated antibody, lyophilized powder

description

~1 mg/mL, fractionated antiserum, buffered aqueous solution

description

clone 1A, buffered aqueous solution

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

-

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

fractionated antiserum

antibody form

ascites fluid

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

1A, monoclonal

Gene Information

mouse ... Cacna1c(12288)
rat ... Cacna1c(24239)

Gene Information

human ... CACNA1C(775)
mouse ... Cacna1c(12288)
rat ... Cacna1c(24239)

Gene Information

human ... CACNB1(782)
mouse ... Cacnb1(12295)
rat ... Cacnb1(50688)

Gene Information

human ... CACNA1S(779)
mouse ... Cacna1s(12292)
rat ... Cacna1s(682930)

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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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