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C1230

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

≥90% (TLC), powder

Synonym(s):

Z-IETD-FMK

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Pack SizeSKUAvailabilityPrice
1 mg
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$762.00

About This Item

Empirical Formula (Hill Notation):
C30H43FN4O11
CAS Number:
220760-26-9
Molecular Weight:
654.68
NACRES:
NA.77
PubChem Substance ID:
329774744
UNSPSC Code:
12352209
MDL number:
MFCD01861686
Assay:
≥90% (TLC)
Form:
powder
Quality level:
200

$762.00

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biological source

synthetic (organic)

Quality Level

200

assay

≥90% (TLC)

form

powder

solubility

methanol: 10 mg/mL, DMSO: 20 mM, clear, colorless to light yellow

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF

InChI

1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1

InChI key

CTXDBLYOEUERAT-VUVYEONESA-N

Application

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:
  • to study the activity of caspase-8 in porcine kidney cells[1]
  • to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells[2]
  • to study its effects on retinal ganglion and astroglia in rat eyes[3]

Biochem/physiol Actions

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.[4]

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
C1480C2105B2682
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone ≥90% (TLC), powder

Sigma-Aldrich

C1230

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

Z-Phe-Ala fluoromethyl ketone ≥90% (TLC), powder

Sigma-Aldrich

C1480

Z-Phe-Ala fluoromethyl ketone

Z-Val-Ala-Asp fluoromethyl ketone powder, ≥90% (TLC)

Sigma-Aldrich

C2105

Z-Val-Ala-Asp fluoromethyl ketone

Boc-Asp(OMe)-fluoromethyl ketone ≥90% (TLC), solid

Sigma-Aldrich

B2682

Boc-Asp(OMe)-fluoromethyl ketone

assay

≥90% (TLC)

assay

≥90% (TLC)

assay

≥90% (TLC)

assay

≥90% (TLC)

form

powder

form

powder

form

powder

form

solid

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

methanol: 10 mg/mL, DMSO: 20 mM, clear, colorless to light yellow

solubility

DMSO or DMF: 20 mM

solubility

-

solubility

DMF: soluble

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCG0101
SLCC0510
SLBW7929
SLBV1990
SLBS2430V

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Yanjie Kong et al.
International journal of cancer, 145(5), 1371-1381 (2019-02-27)
The Cullin 7 (CUL7) gene encodes a member of the cullin family of E3 ubiquitin ligases. Accumulated evidence suggests that CUL7 is oncogenic. However, the mechanism by which CUL7 improves cancer cell survival has not been fully elucidated. Here, we
Lina Hu et al.
Journal of the American Heart Association, 8(24), e005886-e005886 (2019-12-17)
Background Although apoptosis and cell proliferation have been extensively investigated in atherosclerosis and restenosis postinjury, the communication between these 2 cellular events has not been evaluated. Here, we report an inextricable communicative link between apoptosis and smooth muscle cell proliferation
Tina M Sauerwald et al.
Biotechnology and bioengineering, 81(3), 329-340 (2002-12-11)
Apoptosis in mammalian cell culture is associated with decreased bioproduct yields and can be inhibited through altering the intracellular signaling pathways mediating programmed cell death. In this study, we evaluated the capacity to inhibit caspases to maintain high viable cell
View All Related Papers

Global Trade Item Number

SKUGTIN
C1230-1MG04061833461952

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