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C2010

Concanavalin A from Canavalia ensiformis (Jack bean)

Type IV, lyophilized powder

Synonyme(s) :

Con A

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25 mg
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36.60 CHF
100 mg
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90.30 CHF
250 mg
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187.00 CHF
1 g
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395.00 CHF

A propos de cet article

Numéro CAS:
11028-71-0
UNSPSC Code:
23151817
EC Number:
234-258-2
NACRES:
NA.32
MDL number:
MFCD00071069
Form:
lyophilized powder

36.60 CHF

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type

Type IV

Quality Segment

300

form

lyophilized powder

potency

<64 μg per mL agglutination activity

impurities

Carbohydrate, essentially free, salt, essentially free

storage temp.

−20°C

General description

Concanavalin A (con A) is a plant lectin refined from jack beans. It is a tetrameric protein, which has four identical 28 kDa subunits. Con A has the ability to connect with the mannose residues of several glycoproteins and can stimulate lymphocytes.

Application

Concanavalin A from Canavalia ensiformis (Jack bean) has been used:
  • as T-lymphocyte mitogen in lymphocyte proliferation assay for correlations with organochlorine contaminants (OCs)
  • for in vitro stimulation of T cell hybridomas, BW5147 cells and primary CD4+ T cells for T cell vaccination and for induction of hepatitis
  • for the stimulation of mice splenocytes in the suppression of T-lymphocytes proliferation assay
  • for the stimulation of spleen in mitogen assays

Biochem/physiol Actions

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Analysis Note

Highly purified by specific affinity chromatography
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.

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Concanavaline&nbsp;A from Canavalia ensiformis (Jack bean) agarose conjugate, Type VI, saline suspension

Sigma-Aldrich

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Concanavaline A from Canavalia ensiformis (Jack bean)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

saline suspension

impurities

Carbohydrate, essentially free, salt, essentially free

impurities

Carbohydrate, essentially free

impurities

Carbohydrate, essentially free, salt, essentially free

impurities

-

potency

<64 μg per mL agglutination activity

potency

-

potency

≤20 μg per mL agglutination activity

potency

-

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

type

Type IV

type

Type IV

type

Type VI

type

Type VI

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

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Health hazard
GHS08

signalword

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Hazard Classifications

Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Classe de stockage

13 - Non Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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